PEPTIDE MEDIATED SYNTHESIS OF METALLIC AND MAGNETIC MATERIALS

• US 20080287654A1
• Filed: 02/19/2008
• Published: 11/20/2008
• Est. Priority Date: 09/18/2002
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Mao, Chuanbin, Belcher, Angela M., Solis, Daniel J., Reiss, Brian D.
• Application Number:
  US12/033,393
• Publication Number:
  US 20080287654A1
• Time in Patent Office: Days
• US Class Current: 530/333
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C07K 7/00 Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
• CPC Class Codes: C07K 7/06 having 5 to 11 amino acids
• CPC Class Codes: C07K 7/08 having 12 to 20 amino acids gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68
• CPC Class Codes: C12N 15/1037 Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
• CPC Class Codes: C40B 30/04 by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• CPC Class Codes: G01N 33/531 Production of immunochemical test materials
• CPC Class Codes: G01N 33/54326 Magnetic particles

Abstract

The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.

Claims

1. A method of making a magnetic material comprising the steps of:

providing a molecule comprising a portion that binds specifically to the surface of a magnetic material; and

contacting one or more magnetic material precursors with the molecule under conditions that permit formation of the magnetic material.

4. The method of claim 1, wherein the molecule comprises an amino acid oligomer as the portion that binds specifically to the surface of the magnetic material.

5. The method of claim 1, wherein the molecule is selected from a combinatorial library screen.

6. The method of claim 1, further comprising the steps of isolating the magnetic material.

7. The method of claim 1, wherein the molecule is defined further as peptide that comprises a portion of a self-assembling molecule.

8. The method of claim 7, wherein the self-assembling molecule is a phage.

9. The method of claim 1, wherein the magnetic material is a nanoparticle.

10. The method of claim 1, wherein the molecule comprises a chimeric protein that exposes one or more magnetic material binding amino acid oligomers on its surface.

2. A method of making a magnetic material comprising the step of:

contacting a molecule that initiates magnetic material formation with magnetic material precursor and a reducing agent.

3. A method of making a magnetic material comprising the steps of:

linking a magnetic material binding molecule to a substrate;

contacting one or more magnetic material precursors with the magnetic material binding molecule under conditions that form the magnetic material; and

forming the magnetic material.

11. A magnetic material formed using a binding molecule and one or more magnetic material precursors.

13. The magnetic material of claim 11, wherein the magnetic material comprises nanoparticles.

12. A magnetic material formed using a magnetic material specific binding molecule in the presence of a metal salt and a reducing agent.

14. A composition comprising peptide that binds specifically to ε

-Co.

15. A composition comprising peptide that binds specifically to CoPt.

16. A composition comprising peptide that binds specifically to FePt.

17. A composition comprising peptide that binds specifically to SmCo5.

18. A composition comprising peptide that binds specifically to a ferromagnetic surface.

19. A method of isolating a molecule that binds specifically to a magnetic material comprising the steps of:

contacting a library of molecules with a magnetic material;

removing non-binding molecules from the library; and

eluting the bound molecules from the magnetic material.

20. The method of claim 19, wherein the molecular library is further defined as comprising a phage display library.

21. The method of claim 19, wherein the molecular library is further defined as comprising a combinatorial chemistry library.

22. The method of claim 19, wherein the molecules comprise amino acid oligomers which specifically bind the magnetic material.

23. A method of preparing a particle film comprising the steps of:

adding a solution of particles to a surface;

wherein the particles are synthesized with use of binding molecules;

evaporating the solution of nanoparticles on the surface; and

annealing the particles to the surface to create a film of particles.

24. The method of claim 23, wherein the particles are nanoparticles.

25. A method of making a metal material comprising the steps of:

providing a molecule comprising a portion that binds specifically to a metal surface; and

contacting one or more metal material precursors with the molecule under conditions that permit formation of the metal material.

26. A method of making a magnetic material comprising the step of contacting a molecule which binds specifically to the magnetic material with a magnetic material precursor at a temperature of 300°

C. or below to form the magnetic material.

27. A method of making a metallic material comprising the step of contacting a molecule which binds specifically to the metallic material with a metallic material precursor at a temperature of 300°

C. or below to form the metallic material.

28. A composition comprising an oligopeptide and a magnetic material, wherein the oligopeptide is specifically bound to the magnetic material.

29. A composition comprising SmCo5 nanoparticles.

30. A metal material comprising binding molecule-synthesized metal particles.

31. A metal material comprised of a collection of binding molecule synthesized metal nanoparticles that are annealed from polycrystalline to single crystalline materials.

32. A metal material comprising of a collection of binding molecule synthesized metal nanoparticles that are synthesized independently from viruses.