Systems and Methods for Model-Based Estimation of Cardiac Output and Total Peripheral Resistance
First Claim
1. A method for estimating beat-by-beat cardiovascular parameters and variables, comprising:
- processing one or more cycles of arterial blood pressure to determine intra-beat and inter-beat variability in blood pressure; and
computing estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, and a beat-to-beat averaged Windkessel model of an arterial tree.
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Abstract
The methods and systems for estimating cardiac output and total peripheral resistance include observing arterial blood pressure waveforms to determine intra-beat and inter-beat variability in arterial blood pressure and estimating from the variability a time constant for a lumped parameter beat-to-beat averaged Windkessel model of the arterial tree. Uncalibrated cardiac output and uncalibrated total peripheral resistance may then be calculated from the time constant. Calibrated cardiac output and calibrated total peripheral resistance may be computed using calibration data, assuming an arterial compliance that is either constant or dependent on mean arterial blood pressure. The parameters of the arterial compliance may be estimated in a least-squares manner.
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Citations
62 Claims
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1. A method for estimating beat-by-beat cardiovascular parameters and variables, comprising:
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processing one or more cycles of arterial blood pressure to determine intra-beat and inter-beat variability in blood pressure; and computing estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, and a beat-to-beat averaged Windkessel model of an arterial tree. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A system for estimating beat-to-beat cardiac output comprising:
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a blood pressure measuring device; a processor; a display; a user interface; and a memory storing computer executable instructions, which when executed by the processor cause the processor to; receive one or more cycles of arterial blood pressure from the blood pressure device; analyze one or more cycles of arterial blood pressure to determine intra-beat and inter-beat variability in blood pressure; compute estimates of one or more cardiovascular system parameters and variables from the intra-beat variability, the inter-beat variability, and a beat-to-beat averaged Windkessel model of an arterial tree; and display the estimates. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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Specification