Method of evaluating gastroparesis using an ingestible capsule
First Claim
1. A method of evaluating gastroparesis comprising the steps of:
- providing an ingestible capsule having a pH sensor and a pressure sensor;
having a subject ingest said capsule;
recording pH measurements from said pH sensor as a function of time as said capsule moves through at least a portion of the gastrointestinal tract of said subject;
recording pressure measurements from said pressure sensor as a function of time as said capsule moves through at least a portion of said gastrointestinal tract of said subject;
determining said capsules location at a position in said gastrointestinal tract;
deriving a pressure pattern as a function of time and said pressure measurements;
providing a reference pressure pattern; and
analyzing said subject'"'"'s pressure pattern relative to said reference pressure pattern to evaluate said subject with respect to gastroparesis.
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Accused Products
Abstract
A method of evaluating gastroparesis comprising the steps of providing an ingestible capsule having a pH sensor and a pressure sensor, having a subject ingest the capsule, recording pH measurements from the pH sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, recording pressure measurements from the pressure sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, determining the capsule'"'"'s location at a first position in the gastrointestinal tract, deriving a pressure pattern as a function of time and the pressure measurements, providing a reference pressure pattern, and analyzing the subject'"'"'s pressure pattern relative to the reference pressure pattern to evaluate the subject with respect to gastroparesis. The location may be the junction between the stomach and the small bowel of the subject. The pressure pattern may be the number of contractions relative to a baseline over a given time interval or area under the curve of pressure measurements over a given time interval.
43 Citations
34 Claims
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1. A method of evaluating gastroparesis comprising the steps of:
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providing an ingestible capsule having a pH sensor and a pressure sensor; having a subject ingest said capsule; recording pH measurements from said pH sensor as a function of time as said capsule moves through at least a portion of the gastrointestinal tract of said subject; recording pressure measurements from said pressure sensor as a function of time as said capsule moves through at least a portion of said gastrointestinal tract of said subject; determining said capsules location at a position in said gastrointestinal tract; deriving a pressure pattern as a function of time and said pressure measurements; providing a reference pressure pattern; and analyzing said subject'"'"'s pressure pattern relative to said reference pressure pattern to evaluate said subject with respect to gastroparesis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method of evaluating gastroparesis comprising the steps of:
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providing an ingestible capsule having a pH sensor; having a subject ingest said capsule; recording pH measurements from said pH sensor as a function of time as said capsule moves through at least a portion of the gastrointestinal tract of said subject; determining said capsules position at a junction between the stomach and the small bowel of said subject as a function of said pH measurements; determining a transit time of said capsule between the time said capsule is ingested by said subject and the time said capsule is determined to be at said position; providing a reference transit time; and evaluating said transit time relative to said reference transit time. - View Dependent Claims (32, 33, 34)
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Specification