Methods and compositions for the treatment of pain
First Claim
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1. A method of treating pain in a patient in need thereof, said method comprising topically administering to said patient an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat said pain.
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Abstract
The invention features methods, kits, and compositions for the treatment of pain.
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Citations
46 Claims
- 1. A method of treating pain in a patient in need thereof, said method comprising topically administering to said patient an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat said pain.
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2. A method of treating pain at a site in a patient in need thereof, said method comprising locally injecting at said site an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat said pain.
- 3. A method of treating pain in a patient in need thereof, said method comprising administering to said patient an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat said pain, wherein said pain is nociceptive pain, somatic pain, visceral pain, procedural pain, or inflammatory pain caused by trauma, surgery, or an autoimmune disease.
- 5. A method of treating itch in a patient in need thereof, said method comprising topically administering to said patient an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat said itch.
- 17. A kit comprising (i) a composition comprising an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat pain when administered to a patient, and (ii) instructions for topically administering said composition to a patient for the treatment of pain.
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20. A kit comprising (i) a composition formulated for injection and comprising an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat pain when administered to a patient, and (ii) instructions for locally injecting said composition at a site of a patient for the treatment of pain.
- 21. A kit comprising (i) a composition comprising an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat pain when administered to a patient, and (ii) instructions for administering said composition to a patient for the treatment of nociceptive pain, somatic pain, visceral pain, procedural pain, or inflammatory pain caused by trauma, surgery, or an autoimmune disease.
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23. A kit comprising (i) a composition comprising an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat itch when administered to a patient, and (ii) instructions for topically administering said composition to a patient for the treatment of itch.
- 31. A kit comprising (i) an inorganic oxide, (ii) an ammonium salt, (iii) a hypochlorite salt, (iv) instructions for contacting said inorganic oxide, said ammonium salt, and said hypochlorite salt with water to form a solution, and (v) instructions for administering said solution to a patient for the treatment of pain or itch.
- 35. A bandage comprising an agent selected from N-chloro amines and N-dichloro amines in an amount sufficient to treat pain or itch when applied to the skin of a patient.
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44. An infusion device comprising:
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(i) a first reservoir containing a first solution comprising an ammonium salt or an amine or a salt thereof; (ii) a second reservoir containing a second solution comprising hypochlorous acid or a salt thereof; (iii) a mixing chamber for combining said first solution and said second solution to form a chlorinated amine; and (iv) a cannula in fluid communication with said mixer chamber for delivering said N-chloro amine to a subject.
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45. An infusion device comprising:
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(i) a reservoir containing a first solution comprising an ammonium chloride salt and/or an amine and chloride ion; (ii) a power source electrically connected to an electrode in contact with said solution and configured to produce N-chloro amine via electrolysis; and (iii) a cannula in fluid communication with said solution for delivering said N-chloro amine to a subject.
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46. An infusion device comprising:
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(i) a first reservoir containing a first solution comprising an amine or a salt thereof; (ii) a second reservoir containing a second solution comprising a chloride ions; (iii) a power source electrically connected to an electrode in contact with said second solution and configured to produce hypochlorous acid or a salt thereof via electrolysis; (iv) a mixing chamber for combining said first solution and said hypochlorous acid or a salt thereof to form an N-chloro amine; and (v) a cannula in fluid communication with said mixing chamber for delivering said N-chloro amine to a subject.
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Specification