Dispensing system for tissue sealants

• US 20080287987A1
• Filed: 06/15/2007
• Published: 11/20/2008
• Est. Priority Date: 05/16/2007
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Ishikawa, Muriel Y., Smith, Michael A., Weaver, Thomas A., Myhrvold, Nathan P., Tegreene, Clarence T., Boyden, Edward S., Whitmer, Charles, Wood, Lowell L. JR., Rivet, Dennis J., Hyde, Roderick A., Wood, Victoria Y.H., Leuthardt, Eric C.
• Application Number:
  US11/818,884
• Publication Number:
  US 20080287987A1
• Time in Patent Office: Days
• US Class Current: 606/214
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/072 for applying a row of staples in a single action , e.g. the staples being applied simultaneously
• CPC Class Codes: A61B 2017/00022 Sensing or detecting at the treatment site
• CPC Class Codes: A61B 2017/00221 with wireless transmission of data, e.g. by infrared radiation or radiowaves
• CPC Class Codes: A61B 2017/00398 using powered actuators, e.g. stepper motors, solenoids
• CPC Class Codes: A61B 2017/00402 Piezo electric actuators
• CPC Class Codes: A61B 2017/00871 polymeric
• CPC Class Codes: A61B 2017/07214 Stapler heads
• CPC Class Codes: A61B 2017/07278 characterised by its sled or its staple holder
• CPC Class Codes: A61B 2017/2905 flexible

Abstract

The present invention discloses a medical device comprising a dispenser adapted to dispense a tissue sealant or one or more precursor compounds, the dispenser being operably coupled to a surgical stapler, which in turn is configured to deliver one or more surgical staples or fasteners in an area of bodily tissue approximation surface. Furthermore, the medical device comprises a dispenser adapted to dispense a tissue sealant or one or more precursor compounds thereof, the dispenser being operably coupled to a surgical cutter. Additionally or alternatively the medical; device can include a microactuation mechanism, whereby the dispenser dispenses the tissue sealant or one or more precursor compounds at a surgical cutting site or in a proximity thereof.

Claims

1. A medical device, comprising:

a dispenser adapted to dispense a tissue sealant or one or more precursor compounds, said dispenser being operably coupled to a surgical stapler, wherein said surgical stapler is configured to deliver one or more surgical staples or fasteners in an area of bodily tissue approximation surface.

2. The medical device of claim 1, wherein said one or more surgical staples or fasteners have at least one coating or covering containing said tissue sealant or said one or more precursor compounds.

3. The medical device of claim 1, wherein said one or more surgical staples or fasteners are either pre-coated or post-coated with said tissue sealant or said one or more precursor compounds.

4. The medical device of claim 1, wherein said one or more surgical staples or fasteners are either partially coated or fully coated with said tissue sealant or said one or more precursor compounds.

5. The medical device of claim 1, wherein said tissue sealant is formed through at least one reaction that includes one or more of said one or more precursor compounds.

6. The medical device of claim 5, wherein said at least one reaction includes one of a reaction or a reaction with endogenous substrates, interaction with an endogenous clotting cascade of a bloodstream, a photo reaction with either a endogenously-generated photons or photons generated external to a bodily tissue or a thermally-driven reaction or a catalytically-activated reaction.

9. The medical device of claim 1, wherein said dispenser is operably configured to dispense microfluidic amounts of said tissue sealant or said one or more precursor compounds.

10. The medical device of claim 1, wherein said dispenser includes one or more micropipettes that dispense said tissue sealant or said one or more precursor compounds.

11. The medical device of claim 1, wherein said dispenser includes one or more micron-sized outlet ports that dispense said tissue sealant or one or more precursor compounds.

12. The medical device of claim 1, wherein said dispenser includes one or more microchips containing said tissue sealant or said one or more precursor compounds.

13. The medical device of claim 1, wherein said dispenser includes one or more arrays of microchips containing more than one type of tissue sealant or said one or more precursor compounds.

14. The medical device of claim 1, wherein said dispenser includes one or more arrays of micropipettes that dispense more than one type of tissue sealant or said one or more precursor compounds.

17. The medical device of claim 1, wherein said tissue sealant or said one or more precursor compounds include at least one of antibacterial agents, anti-infection agents, angiogenic factors, growth factors, blood coagulants, antimicrobial agents, pharmaceuticals, drugs or compounds.

18. The medical device of claim 1, wherein said tissue sealant or said one or more precursor compounds reduces scar formation in body tissue.

19. The medical device of claim 1, wherein said tissue sealant or said one or more precursor compounds include at least one of an acrylic acid-derivative.

20. The medical device of claim 1, wherein said tissue sealant or said one or more precursor compounds include at least one of a gel, a cream, a liquid, a fluid, a semi-solid or solid.

21. The medical device of claim 1, wherein said tissue sealant or said one or more precursor compounds include at least one of a hydrogel, an alginate, a zymogen, a glutaraldehyde-treated protein, a cross-linked protein, a cross-linked carbohydrate or a cross-linked fatty acid derivative.

7. (canceled)

8. (canceled)

15. (canceled)

16. (canceled)

22-125. -125. (canceled)

126. A method of applying tissue sealant to an area of a tissue approximation surface comprising:

dispensing a selected amount of said tissue sealant or one or more precursor compounds, said dispensing occurring through a dispenser that is operably coupled to a surgical device.

127. The method of claim 126, wherein said surgical device is a surgical stapler, a surgical fastener, a trocar device, a surgical cutter or a suturer.

129. The method of claim 126, wherein said dispensing includes location of a site of at least one surgical cut, a surgical suture or a trocar site, or a needle puncture site, or a drain or an entry site of a percutanously inserted or deployed medical device sites are covered with said tissue sealant or said one or more precursor compounds in a body tissue.

131. The method of claim 126, wherein said dispensing includes application of therapeutic amounts of said tissue sealant or said one or more precursor compounds for purposes of inducing anti-infection response, angiogenesis, promoting tissue growth, enhancing blood coagulation, antimicrobial activity or antiviral response.

132. The method of claim 126, wherein said dispensing includes application of amounts of said tissue sealant or said one or more precursor compounds that will hold said tissue approximation surface together for wound healing purposes.

133. The method of claim 126, wherein said dispensing includes pre-coating a staple or fastener with a therapeutic amount of said tissue sealant or said one or more precursor compounds sufficient to promote anti-infection, angiogenesis, tissue growth, blood coagulation, antimicrobiosis or antiviremia.

134. The method of claim 126, wherein said dispensing includes coating a staple or fastener following tissue stapling or fastening with a therapeutic amount of said tissue sealant or said one or more precursor compounds sufficient to promote tissue repair, welding blood vessels, anti-infection, angiogenesis, tissue growth, blood coagulation, antimicrobiosis or antiviremia.

138. The method of claim 126, wherein said area of a tissue approximation surface includes at least one of a blood vessel, a nerve, a cartilage, a bone, a stomach, a pulmonary artery, a vein, a thoraco-abdominal cavity, an intestine, a duodenum, a skin, a fascia, a dermis, a muscle, a meningeal layer, a bowel wall or a mucosal layer.

128. (canceled)

130. (canceled)

135-137. -137. (canceled)

139-153. -153. (canceled)