RADIOPAQUE MARKERS COMPRISING BINARY ALLOYS OF TITANIUM

• US 20080288056A1
• Filed: 05/15/2007
• Published: 11/20/2008
• Est. Priority Date: 05/15/2007
• Status: Active Grant

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Simpson, John A., Boylan, John F.
• Granted Patent: US 8,500,786 B2
• Time in Patent Office: Days
• US Class Current: 623/1.34
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers

Abstract

There is disclosed a radiopaque marker comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed various medical devices, such as stents, guidewires and embolic filters, that have the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosed.

Claims

1. A radiopaque marker comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold.

2. The radiopaque marker of claim 1, wherein titanium is present in an amount ranging from 45 to 55 atomic percent, with the balance comprising said binary element.

3. The radiopaque marker of claim 2, wherein titanium is present in an amount ranging from 49 to 51 atomic percent, with the balance comprising said binary element.

4. The radiopaque marker of claim 1, wherein the binary titanium alloy comprises equiatomic binary alloys chosen from Ti50Pt50, Ti50Pd50, Ti50Rh50, and Ti50Au50.

5. The radiopaque marker of claim 1, which is integrally attached to a superelastic alloy.

6. The radiopaque marker of claim 5, wherein said superelastic alloy comprises a binary nickel-titanium alloy or a ternary alloy containing nickel and titanium.

7. The radiopaque marker of claim 6, wherein said ternary alloy containing nickel and titanium comprises at least one ternary element chosen from platinum, palladium, gold and rhodium.

8. The radiopaque marker of claim 5, which comprises a weld between said radiopaque marker and said superelastic alloy.

9. The radiopaque marker of claim 5, wherein said superelastic alloy is expandable or self-expandable.

10. The radiopaque marker of claim 9, wherein the superelastic alloy is a ternary alloy of nickel, titanium, and platinum.

11. The radiopaque marker of claim 10, wherein the ternary alloy comprises 49 to 51 atomic percent titanium, 7 to 8 atomic percent platinum, the remainder comprising nickel.

12. A medical device comprising a radiopaque marker, said radiopaque marker comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold.

13. The medical device of claim 12, wherein titanium is present in said radiopaque marker in an amount ranging from 45 to 55 atomic percent, with the balance comprising said binary element.

14. The medical device of claim 13, wherein titanium is present in an amount ranging from 49 to 51 atomic percent, with the balance comprising said binary element.

15. The medical device of claim 14, wherein the binary titanium alloy comprises equiatomic binary alloys chosen from Ti50Pt50, Ti50Pd50, Ti50Rh50, and Ti50Au50.

16. The medical device of claim 12, wherein said radiopaque marker is integrally attached to a superelastic alloy.

17. The medical device of claim 16, wherein said superelastic alloy comprises a binary nickel-titanium alloy or a ternary alloy of nickel and titanium.

18. The medical device of claim 17, wherein said ternary alloy of nickel and titanium comprises at least one ternary element chosen from platinum, palladium, gold and rhodium.

19. The medical device of claim 16, which comprises a weld between said radiopaque marker and said superelastic alloy for integrally attaching said radiopaque marker and said superelastic alloy.

20. The medical device of claim 16, wherein said superelastic alloy is expandable or self-expandable.

21. The medical device of claim 18, wherein the superelastic alloy is a ternary alloy of nickel, titanium, and platinum.

22. The medical device of claim 21, wherein the ternary alloy comprises 49 to 51 atomic percent titanium, 7 to 8 atomic percent platinum, the remainder comprising nickel.

23. The medical device of claim 12, which is a stent, guidewire, or embolic protection device.

24. A stent delivery system comprising:

an expandable or self-expanding section; and

a radiopaque marker integrally attached to said expandable or self-expanding section, wherein said radiopaque marker comprises a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold.

25. The stent delivery system of claim 24, wherein titanium is present in said radiopaque marker in an amount ranging from 45 to 55 atomic percent, with the balance comprising said binary element.

26. The stent delivery system of claim 25, wherein titanium is present in an amount ranging from 49 to 51 atomic percent, with the balance comprising said binary element.

27. The stent delivery system of claim 26, wherein the binary titanium alloy comprises equiatomic binary alloys chosen from Ti50Pt50, Ti50Pd50, Ti50Rh50, and Ti50Au50.

28. The stent delivery system of claim 24, wherein said radiopaque marker is integrally attached to said expandable or self-expanding section by a weld.

29. The stent delivery system of claim 24, wherein said expandable or self-expanding section comprises a binary nickel-titanium alloy or a ternary alloy of nickel and titanium.

30. The stent delivery system of claim 29, wherein said ternary alloy of nickel and titanium comprises at least one ternary element chosen from platinum, palladium, gold and rhodium.

31. The stent delivery system of claim 24, which comprises a weld between said radiopaque marker and said superelastic alloy for integrally attaching said radiopaque marker and said superelastic alloy.

32. The stent delivery system of claim 24, wherein said ternary alloy of nickel and titanium comprises platinum.

33. The stent delivery system of claim 32, wherein the ternary alloy comprises 49 to 51 atomic percent titanium, 7 to 8 atomic percent platinum, the remainder comprising nickel.

34. The stent delivery system of claim 24, further comprising a guidewire.

35. The stent delivery system of claim 34, wherein said guidewire has said radiopaque marker attached thereto.

36. A method of fabricating a medical device comprising a radiopaque marker, said method comprising:

welding to an expandable or self-expanding section, a radiopaque marker comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold.

37. The method of claim 36, wherein titanium is present in said radiopaque marker in an amount ranging from 45 to 55 atomic percent, with the balance comprising said binary element.

38. The method of claim 37, wherein titanium is present in an amount ranging from 49 to 51 atomic percent, with the balance comprising said binary element.

39. The method of claim 38, wherein the binary titanium alloy comprises equiatomic binary alloys chosen from Ti50Pt50, Ti50Pd50, Ti50Rh50, and Ti50Au50.

40. The method of claim 36, wherein said welding comprises fusion welding.

41. The method of claim 36, wherein said expandable or self-expanding section comprises a binary of nickel-titanium or a ternary alloy of nickel and titanium.

42. The method of claim 41, wherein said ternary alloy of nickel and titanium comprises at least one ternary element chosen from platinum, palladium, gold and rhodium.

43. The method of claim 42, wherein said ternary alloy of nickel and titanium comprises platinum.

44. The method of claim 43, wherein the ternary alloy comprises 49 to 51 atomic percent titanium, 7 to 8 atomic percent platinum, the remainder comprising nickel.

45. The method of claim 36, wherein said medical device is chosen from a stent, guidewire, or embolic protection device.