BIOLOGICAL SIMULATION SYSTEM AND COMPUTER PROGRAM PRODUCT
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Abstract
With an object to seek parameters of a biological model corresponding to individual patents, the present invention provides a biological simulation system comprises an internal parameter set generating section which generates internal parameter sets constituting a biological model, a biological model computing section computing output of a biological model which emulates a biological response of a biological organ based on the generated internal parameter set, and a template database having a plurality of combinations of a reference output value of the biological model and an internal parameter set corresponding to the reference output value, wherein the internal parameter set generating section comprises a database referring means which selects a reference output approximate to an actual biological response from said template database and which selects an internal parameter set corresponding to the selected reference output value.
11 Citations
40 Claims
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1-20. -20. (canceled)
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21. A biological simulation system for producing a biological function profile of a diabetic patient, comprising:
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receiving means for receiving an input of time-series data of an oral glucose tolerance test of the diabetic patient; a template database comprising a plurality of different internal parameter sets and a plurality of different reference time-series data, each of the reference time-series data corresponding to each of the internal parameter sets; database reference means for selecting the internal parameter set from the template database, the selected internal parameter set corresponding to the reference time-series data most similar to the input oral glucose tolerance test time-series data; and biological function profile producing means for producing a biological function profile based on the selected internal parameter set. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. A biological simulation system for producing a biological function profile of a diabetic patient, comprising:
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receiving means for receiving an input of time-series data of an oral glucose tolerance test of the diabetic patient; a template database comprising a plurality of different internal parameter sets and a plurality of different reference time-series data, each of the reference time-series data corresponding to each of the internal parameter sets; database reference means for selecting the internal parameter set from the template database, the selected internal parameter set corresponding to the reference time-series data most similar to the input oral glucose tolerance test time-series data; search range determining means for determining a search range containing the selected internal parameter set; means for automatically generating a plurality of different internal parameter sets within the determined search range; similarity calculating means for calculating similarity between the input oral glucose tolerance test time-series data and each of time-series data corresponding to the generated internal parameter sets; selecting means for selecting the internal parameter set from the generated internal parameter sets, the selected generated internal parameter set corresponding to the time-series data which has highest similarity; and biological function profile producing means for producing a biological function profile based on the selected generated internal parameter set. - View Dependent Claims (29, 30, 31)
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32. A biological simulation system for producing a biological function profile of a diabetic patient, comprising:
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receiving means for receiving an input of time-series data of oral glucose tolerance test of the diabetic patient; a template database comprising a plurality of different internal parameter sets and a different plurality of reference time-series data, each of the reference time-series data corresponding to each of the internal parameter sets; database reference means for selecting the internal parameter set corresponding to the reference time-series data closes to the input oral glucose tolerance test time-series data from the template database; similarity judging means for judging whether similarity between the selected reference time-series data and the input oral glucose tolerance test time-series data is high or not; means for automatically generating a plurality of different internal parameter sets when the similarity judging means has judged that the similarity is not high; similarity calculating means for calculating similarity between the input oral glucose tolerance test time-series data and each of time-series data corresponding to the generated internal parameter sets; selecting means for selecting the internal parameter set from the generated internal parameter sets, the selected generated internal parameter set corresponding to the time-series data which has the highest similarity; and biological function profile producing means for producing a biological function profile based on the selected generated internal parameter set. - View Dependent Claims (33, 34, 35)
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36. A computer program product for enabling a computer to execute a method of producing a biological function profile of a diabetic patient, the computer program product comprising:
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a computer readable medium comprising software instructions for enabling the computer to perform predetermined operations comprising; receiving an input of time-series data of an oral glucose tolerance test of the diabetic patient; selecting an internal parameter set corresponding to a reference time-series data most similar to the input oral glucose tolerance test time-series data from a template database comprising a plurality of different internal parameter sets and a plurality of different reference time-series data, each of the reference time-series data corresponding to each of the internal parameter sets; and producing a biological function profile based on the selected internal parameter set. - View Dependent Claims (37, 38, 39, 40)
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Specification