MELANOMA ANTIGENS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS
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Abstract
The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.
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Citations
71 Claims
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1-66. -66. (canceled)
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67. A recombinant protein encoded by a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 1, or an allelic variation, homolog, or variant thereof.
- View Dependent Claims (69, 70, 71)
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68. An isolated or purified protein comprising the amino acid sequence of SEQ ID NO:
- 2 or a substantially homologous sequence thereof.
Specification