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Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment

  • US 20080293750A1
  • Filed: 01/31/2005
  • Published: 11/27/2008
  • Est. Priority Date: 10/17/2002
  • Status: Abandoned Application
First Claim
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1. A method of prophylaxis therapy for myocardial infarction (MI) comprising:

  • selecting a human subject susceptible to MI;

    administering to the subject a composition comprising a therapeutically effective amount of an MI therapeutic agent that inhibits leukotriene synthesis in vivo, wherein the MI therapeutic agent inhibits leukotriene synthesis by inhibiting the activity of at least one protein selected from 5-Lipoxygenase activating protein (FLAP) and 5-lipoxygenase (5-LO), andmonitoring myeloperoxidase (MPO) level in the human subject before and during the prophylaxis treatment, wherein the MI therapeutic agent is administered in an amount effective to reduce the MPO level in a subject.

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