BIOACTIVE AND BIOCOMPATIBLE POLYURETHANE-BUTHANEDIOL-GLYCOSAMINOGLYCAN SALT COPOLYMERS
First Claim
1. A copolymer comprising the reaction product of a biocompatible urethane and a bioactive polysaccharide.
2 Assignments
0 Petitions
Accused Products
Abstract
A bioactive and biocompatible polyurethane-butanediol-glycosaminoglycan copolymer for use in medical implant devices. The biocompatible urethane component being the reaction product of 4,4′-methylene-di-(p-phenyl isocyanate) and poly(tetramethylene oxide)n and further reacted with 1,4-butanediol, wherein n=10 to 40. The bioactive glycosaminoglycan being a salt of hyaluronic acid, such as a cetylpyridinium salt acid having 5 to 10,000 repeating units or a salt of heparin, such as a dimethyldioctadecylammonium salt of heparin has 5 to 65 repeating units or a suitable salt of dermatan sulfate. The weight content of the bioactive glycosaminoglycan is an amount sufficient to render the copolymer bioactive. The copolymers described herein have excellent hemocompatibility and biocompatibility.
-
Citations
24 Claims
- 1. A copolymer comprising the reaction product of a biocompatible urethane and a bioactive polysaccharide.
-
12. A method of making a bioactive and biocompatible polyurethane-diol-polysaccharide copolymer comprising:
-
reacting a suitable isocyanate-containing molecule and a suitable poly(C2-10 alkylene oxide)n to produce a diisocyanate reactant, and, reacting the diisocyanate reactant with a suitable C4-50 diol-containing molecule and a bioactive polysaccharide, wherein n=10 to 40, wherein the C2-10 alkylene is linear or branched, substituted or un-substituted, and, wherein the C4-50 is linear or branched, substituted or un-substituted. - View Dependent Claims (13, 14, 15, 16, 17, 18)
-
-
19. A method of making a bioactive and biocompatible polyurethane-butanediol-glycosaminoglycan salt copolymer comprising:
-
reacting 4,4′
-methylene-di-(p-phenyl isocyanate) and poly(tetramethylene oxide)n to produce a diisocyanate reactant, and,reacting the diisocyanate reactant with 1,4-butanediol and a bioactive glycosaminoglycan salt selected from the group consisting of a suitable salt of hyaluronic acid and a suitable salt of heparin, wherein n=10 to 40. - View Dependent Claims (20, 21, 22, 23, 24)
-
Specification