System to Measure Blood Coagulation Related Parameters

• US 20080294029A1
• Filed: 11/24/2006
• Published: 11/27/2008
• Est. Priority Date: 11/25/2005
• Status: Abandoned Application

• Current Assignee: Debiotech S.A.
• Original Assignee: Debiotech S.A.
• Inventors: Neftel, Frederic, Piveteau, Laurent-Dominique, Blanc, Nicolas, Metref, Lynda, Vallet, Veronique
• Application Number:
  US12/091,953
• Publication Number:
  US 20080294029A1
• Time in Patent Office: Days
• US Class Current: 600/369
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0655 pinch valves
• CPC Class Codes: B01L 2400/0672 Swellable plugs
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: F04B 43/043 Micropumps
• CPC Class Codes: F16K 2099/008 Multi-layer fabrications
• CPC Class Codes: F16K 2099/0084 Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 2099/0086 Medical applications
• CPC Class Codes: F16K 99/0001 Microvalves microdevices B81B1/00; manufacture or treatment of devices or systems in or on a substrate B81C1/00; microfluidic structures B01L3/5027; micropumps F04B19/006
• CPC Class Codes: F16K 99/0026 Valves using channel deformation
• CPC Class Codes: F16K 99/0036 operated by temperature variations
• CPC Class Codes: F16K 99/004 using radiation
• CPC Class Codes: F16K 99/0061 actuated by an expanding gas or liquid volume
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 33/4905 : Determining clotting time of blood by chemical methods G01N33/86, C12Q1/54
• CPC Class Codes: Y10T 137/2191 : By non-fluid energy field affecting input [e.g., transducer]
• CPC Class Codes: Y10T 137/2196 : Acoustical or thermal energy

Abstract

System to measure blood coagulation related parameters comprising one first channel (6) adapted to contain a blood sample; said system containing, at least partially, an expandable material which is able to increase its volume when activated by an exciting source; said system furthermore comprising several excitable regions distributed close to said first channel (6), in such a way that, when one of said excitable region is activated, said expandable material increases to such an extend that the channel cross section is reduced to a location situated at or near to said excitable region.

Claims

1. System to measure blood coagulation related parameters comprising one first channel adapted to contain a blood sample;

said system containing, at least partially, an expandable material which is able to increase its volume when activated by an exciting source;

said system furthermore comprising several excitable regions distributed close to said first channel, in such a way that, when one of said excitable region is activated, said expandable material increases to such an extend that the channel cross section is reduced at a location situated at or near to said excitable region.

2. System according to claim 1 furthermore comprising at least a second channel, said second channel being parallel to and communication at one of its end with said first channel.

3. System according to claim 1 wherein said material is adapted to be activated by heat, light, pH variation or by a chemical, electromagnetic or radioactive element as exciting factor.

4. System according to claim 1 wherein said material is a mixture comprising Expancel®

.

5. System according to claim 1 in combination with an exciting source, such as a laser, which is distinct from said system.

6. System according to claim 1 furthermore comprising an exciting source such as an electrical resistance.

7. System according to claim 1 wherein said channel is defined by two horizontal and two lateral walls.

8. System according to claim 7 wherein at least one of said horizontal walls is made of said expandable material.

9. System according to claim 1 wherein said channel cross section is adapted to be reduced along a vertical direction.

10. System according to claim 7 wherein both lateral walls are made of said expandable material.

11. System according to claim 10 wherein said channel cross section is adapted to be reduced along a horizontal direction.

12. System according to claim 1 wherein the said material is expandable and is a mixture comprising PDMS or a biocompatible material.

13. System according to claim 1 wherein said channel(s) comprise(s) at least a region of narrowing.

14. System according to claim 1, said system having a multilayered structure comprising successively a substrate layer, an expandable layer, a rigid layer and a cover layer, said substrate layer incorporating said exciting source and said channel(s) being defined in said rigid layer.

15. System according to claim 14 wherein said substrate layer is made of PCB, said expandable layer is made of PDMSXB et said rigid layer is made of PDMS.

16. System according to claim 1 furthermore comprising sensing means.

17. System according to claim 16 wherein said sensing means are diodes, optical density or impedance measuring means.

18. System according to claim 16 wherein said sensing means are adapted to locate where the blood stops.

19. System according to claim 16 wherein said sensing means are adapted to detect blood displacement.

20. Assembly comprising a system as defined in claim 1 in combination with at least one reservoir communicating with said channel(s), said reservoir(s) being adapted to contain reactive which are used in the coagulation tests.

21. Use of a system or an assembly as defined in claim 1 for determining the coagulation time based on the distance made by the liquid along the channel before being stopped, said liquid being moved by a sequential activation of said exciting sources.

22. Use of a multi-channel system or an assembly as defined in claim 1 wherein each channel is used for a test.

23. Use according claim 22 wherein all channels are used for carrying out the same test.

24. Use of a system or an assembly as defined in claim 1 characterized by the use of a pushing fluid which is non miscible with blood and located between blood and the region of the channel being closed.