SYSTEMS AND METHODS FOR MODEL-BASED ESTIMATION OF CARDIAC EJECTION FRACTION, CARDIAC CONTRACTILITY, AND VENTRICULAR END-DIASTOLIC VOLUME
First Claim
1. A method for estimating beat-by-beat cardiovascular parameters and variables, comprising:
- processing one or more cycles of arterial blood pressure to determine intra-beat and inter-beat variability in blood pressure; and
computing estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-by-beat estimates of stroke volume, and a ventricular pressure-volume model.
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Accused Products
Abstract
The methods and systems for estimating cardiac ejection fraction, cardiac contractility, and ventricular end-diastolic volume on a beat-by-beat basis include observing arterial blood pressure waveforms to determine ventricular compliances for a pressure-volume loop in the ventricle. Uncalibrated or calibrated cardiac ejection fraction may be calculated from estimates of stroke volume and the ventricular compliances. Cardiac contractility may be calculated from estimates of a ventricular compliance. Uncalibrated or calibrated ventricular end-diastolic volume may also be calculated from estimates of stroke volume and the ventricular compliances. A set of calibration parameters for calibrating cardiac ejection fraction or ventricular end-diastolic volume may be estimated in a least-squares manner.
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Citations
72 Claims
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1. A method for estimating beat-by-beat cardiovascular parameters and variables, comprising:
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processing one or more cycles of arterial blood pressure to determine intra-beat and inter-beat variability in blood pressure; and computing estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-by-beat estimates of stroke volume, and a ventricular pressure-volume model. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A system for estimating beat-to-beat cardiac output comprising:
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a blood pressure measuring device; a processor; a display; a user interface; and a memory storing computer executable instructions, which when executed by the processor cause the processor to; receive one or more cycles of arterial blood pressure from the blood pressure device; receive beat-to-beat estimates of stroke volume; analyze one or more cycles of arterial blood pressure to determine intra-beat and inter-beat variability in blood pressure; compute estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-to-beat estimates of stroke volume, and a ventricular pressure-volume model; and display the estimates. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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Specification