Coatable Compositions, Coatings Derived Therefrom and Microarrays Having Such Coatings

• US 20080294116A1
• Filed: 11/17/2006
• Published: 11/27/2008
• Est. Priority Date: 11/18/2005
• Status: Active Grant

• Current Assignee: Kindeva Drug Delivery L.P.
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Wolter, James T., Simons, John K., Johnson, Peter R.
• Granted Patent: US 8,900,180 B2
• Time in Patent Office: Days
• US Class Current: 604/173
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.

Claims

1. A microarray comprising:

A plurality of microneedles extending from a support substrate;

A coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt.

2. A microarray according to claim 1 wherein the height of the microneedles is between about 1 μ

m and about 400 μ

m.

3. A microarray according to claim 1 wherein the microneedles each have an aspect ratio of at least about 2:

1.

4. A microarray according to claim 1 wherein the microneedles each have an aspect ratio of at least about 3:

1.

5. A microarray according to claim 1 wherein the microneedles each have an aspect ratio of at least about 5:

1.

6. A microarray according to claim 1 wherein the microarray comprises up to 1000 microneedles extending from a support substrate.

7. A microarray according to claim 1 wherein each microneedle comprises a base portion attached to the support substrate and a tip portion distal from the support substrate, the coating being deposited on the tip portion of at least one of the plurality of microneedles.

8. A microarray according to claim 1 wherein the biological salt is selected from a carboxylated organic salt, a hydroxylated organic salt or a combination of the foregoing.

9. A microarray according to claim 1 wherein the biological salt is a salt of citric acid.

10. A microarray according to claim 9 wherein the salt of citric acid is selected from monosodium citrate, disodium citrate, trisodium citrate, monopotassium citrate, monopotassium citrate, monopotassium citrate, and combinations of two or more of the foregoing.

11. A microarray according to claim 10 wherein the active agent is an antigen adsorbed on an aluminum adjuvant.

12. A microarray according to claim 1 wherein the active agent is a vaccine.