SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS
First Claim
1. A method of providing therapy to a patient, comprising:
- placing at least one electrode in contact with tissue of a patient;
conveying a sub-threshold, hyperpolarizing, conditioning pre-pulse from the at least one electrode to render a first region of the tissue less excitable to stimulation; and
conveying a depolarizing stimulation pulse from the at least one electrode to stimulate a second different region of the tissue.
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Accused Products
Abstract
A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
60 Citations
28 Claims
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1. A method of providing therapy to a patient, comprising:
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placing at least one electrode in contact with tissue of a patient; conveying a sub-threshold, hyperpolarizing, conditioning pre-pulse from the at least one electrode to render a first region of the tissue less excitable to stimulation; and conveying a depolarizing stimulation pulse from the at least one electrode to stimulate a second different region of the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of providing therapy to a patient, comprising:
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placing at least one electrode in contact with tissue of a patient; conveying a sub-threshold, hyperpolarizing, conditioning pre-pulse from the at least one electrode to the tissue, wherein the conditioning pre-pulse has a duration less than 200 μ
s; andconveying a depolarizing stimulation pulse from the electrode to the tissue. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A neurostimulation system, comprising:
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a plurality of electrical contacts; analog output circuitry capable of outputting electrical pulses to the plurality of electrical contacts in accordance with a pulse pattern; and control circuitry capable of defining the pulse pattern, such that the electrical pulses comprise a sub-threshold, conditioning, pre-pulse outputted to a first one of the electrical contacts, and a stimulation pulse outputted to a second different one of the electrical contacts, wherein the conditioning pre-pulse has a duration less than 200 μ
s. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification