Methods and Materials for Connective Tissue Repair
First Claim
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1. A method for repairing a tendon in a patient, the tendon having ruptured into a first tendon portion having a first end portion and a second tendon portion having a second end portion, comprising:
- providing a scaffolding matrix material, said scaffolding matrix material consisting of an off-the-shelf organic dermis from an unknown source which has been extra-operatively prepared so as to be devoid of viable cells which normally express antigens and to promote natural healing of soft tissue via revascularization and repopulation, said scaffolding matrix material having a shelf life of at least 2 years,accessing the tendon,joining the first end portion to the second end portion by attaching said scaffolding matrix material to the first and the second tendon portions.
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Abstract
Methods for tendon and ligament repair using a scaffolding matrix material. The scaffolding matrix material is an off-the-shelf organic dermis from an unknown source which has been extra-operatively prepared so as to be devoid of viable cells which normally express antigens, and to promote natural healing of soft tissue via revascularization and repopulation. The scaffolding matrix material is used to join ruptured tendons or ligaments together and to join ligaments to bone.
53 Citations
20 Claims
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1. A method for repairing a tendon in a patient, the tendon having ruptured into a first tendon portion having a first end portion and a second tendon portion having a second end portion, comprising:
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providing a scaffolding matrix material, said scaffolding matrix material consisting of an off-the-shelf organic dermis from an unknown source which has been extra-operatively prepared so as to be devoid of viable cells which normally express antigens and to promote natural healing of soft tissue via revascularization and repopulation, said scaffolding matrix material having a shelf life of at least 2 years, accessing the tendon, joining the first end portion to the second end portion by attaching said scaffolding matrix material to the first and the second tendon portions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for repairing a tendon in a patient, the tendon having ruptured into a first tendon portion having a first end portion and a second tendon portion having a second end portion, and in which the first and second end portions cannot be re-approximated due to a gap between the first and second end portions, comprising:
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providing a scaffolding matrix material, said scaffolding matrix material consisting of an off-the-shelf organic dermis from an unknown source which has been extra-operatively prepared so as to be devoid of viable cells which normally express antigens and to promote natural healing of soft tissue via revascularization and repopulation, said scaffolding matrix material having a shelf life of at least 2 years, accessing the tendon, attaching said scaffolding matrix material to the first end portion and to the second end portion such that said scaffolding matrix material spans the gap, thereby joining the first and second end portions together via said scaffolding matrix material, and allowing new connective tissue from the patient to first repopulate and then build upon said scaffolding matrix material. - View Dependent Claims (14, 15)
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16. A method of repairing and augmenting a detached ligament in a joint of a patient, the ligament being naturally attached to a first bone of the joint but detached from a second bone of the joint, comprising:
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providing a scaffolding matrix material, said scaffolding matrix material consisting of an off-the-shelf organic dermis from an unknown source which has been extra-operatively prepared so as to be devoid of viable cells which normally express antigens and to promote natural healing of soft tissue via revascularization and repopulation, said scaffolding matrix material having a shelf life of at least 2 years, accessing the joint, attaching said scaffolding matrix material to the second bone portion from which the ligament has become detached; and attaching said scaffolding matrix material along the ligament such that the ligament is augmented by said scaffolding matrix material and such that the first and second bones of the joint are attached to one another via said scaffolding matrix material and the ligament. - View Dependent Claims (17, 18, 19, 20)
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Specification