Silicone Adhesive For Adhesion To Wet Surfaces

• US 20080295960A1
• Filed: 01/03/2007
• Published: 12/04/2008
• Est. Priority Date: 01/19/2006
• Status: Active Grant

• Current Assignee: Dow Corning Corporation (Dow, Inc.)
• Original Assignee: Dow Corning Corporation (Dow, Inc.)
• Inventors: Raul, Victor Albert, Thomas, Xavier Jean-Paul, Gantner, David Clayton, Schalau II, Gerald Kenneth
• Granted Patent: US 7,914,645 B2
• Time in Patent Office: Days
• US Class Current: 156/329
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61K 9/7069 obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
• CPC Class Codes: A61M 2205/0205 Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: C08G 2170/40 Compositions for pressure-sensitive adhesives
• CPC Class Codes: C08L 83/00 Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
• CPC Class Codes: C09J 183/04 Polysiloxanes

Abstract

A silicone adhesive composition used for adhering a device or a substance to a wet surface contains (i) a silicone resin that is cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups; (ii) a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm²/_s at 25° C.; (iii) a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm²/_s at 25° C.; (iv) a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000; and optionally, (v) a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds. Other components such as a silicone polyether, a silicone wax, a drug, an excipient, and/or an active ingredient can also be included.

Claims

1. A silicone adhesive composition comprising:

(i) 13 to 25 weight percent of a silicone resin that is a cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups;

(ii) 8 to 20 weight percent of a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm²/s at 25°

C.;

(iii) 5 to 30 weight percent a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm²/s at 25°

C.;

(iv) 5 to 25 weight percent of a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000; and

optionally,

(v) up to 35 weight percent a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds.

2. A composition according to claim 1 in which the silicone adhesive composition further comprises up to 10 weight percent of a silicone polyether.

3. A composition according to claim 1 in which the silicone adhesive composition further comprises up to 15 weight percent of a silicone wax.

4. A composition according to claim 1 in which the silicone adhesive composition further comprises up to 35 weigh percent of a drug, an excipient and/or an active ingredient.

5. A method of adhering a device or substance to a wet surface comprising applying to the wet surface a silicone adhesive composition, the silicone adhesive composition comprising:

(i) 13 to 25 weight percent of a cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups;

(ii) 8 to 20 weight percent of a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm²/s at 25°

C.;

(iii) 5 to 30 weight percent of a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm²/s at 25°

C.;

(iv) 5 to 25 weight percent of a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000; and

optionally,

(v) up to 35 weight percent of a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds.

6. A method according to claim 5 in which the silicone adhesive composition further comprises up to 10 weight percent of a silicone polyether.

7. A method according to claim 5 in which the silicone adhesive composition further comprises up to 15 weight percent of a silicone wax.

8. A method according to claim 5 in which the silicone adhesive composition further comprises up to 35 weight percent of a drug, an excipient and/or an active ingredient.

9. A method according to claim 5 in which the device is a denture, a hairpiece, a prosthesis, an ostomy, a wound dressing, a tape, a buccal patch, or a transdermal patch.

10. A method according to claim 5 in which the wet surface is skin, the buccal cavity, the gums, the mucosal linings of intranasal passages, the alimentary canal, vaginal and rectal walls, and wet components of botanical origin.