LOW OXYGEN IN VIVO ANALYTE SENSOR
First Claim
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1. A device for measuring a concentration of glucose in a biological fluid, the device comprising:
- a glucose determining apparatus comprising an electrode and a membrane impregnated with glucose oxidase, wherein the glucose determining apparatus is configured to determine, in operation, a concentration of glucose in a biological sample via measurement of hydrogen peroxide produced by a reaction of glucose and oxygen with the glucose oxidase; and
a housing comprising an electronic circuit operatively connected to at least one electrode;
wherein the glucose determining apparatus is configured to measure glucose concentration with substantial linearity at glucose concentrations of up to about 400 mg/dL at an oxygen concentration of less than about 0.6 mg/L.
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
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14 Claims
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1. A device for measuring a concentration of glucose in a biological fluid, the device comprising:
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a glucose determining apparatus comprising an electrode and a membrane impregnated with glucose oxidase, wherein the glucose determining apparatus is configured to determine, in operation, a concentration of glucose in a biological sample via measurement of hydrogen peroxide produced by a reaction of glucose and oxygen with the glucose oxidase; and a housing comprising an electronic circuit operatively connected to at least one electrode;
wherein the glucose determining apparatus is configured to measure glucose concentration with substantial linearity at glucose concentrations of up to about 400 mg/dL at an oxygen concentration of less than about 0.6 mg/L. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification