Systems and Methods for Processing Medical Image Data to Facilitate Comparisons Among Groups of Subjects
First Claim
Patent Images
1. A method for processing medical image data, the method comprising:
- receiving a first three-dimensional image comprising a plurality of voxels;
reducing a regional trend within the three-dimensional image;
computing a semivariogram for a region of interest;
defining at least one block of spatially correlated voxels;
calculating voxel weights for each voxel within the at least one block; and
determining a block average count and variance for the at least one block.
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Abstract
Systems and methods for processing medical image data with increased sensitivity to facilitate comparisons among groups of subjects are disclosed herein. In one embodiment, a method comprises receiving a first three-dimensional image comprising a plurality of voxels, reducing a regional trend within the three-dimensional image, computing a semivariogram for a region of interest, defining at least one block of spatially correlated voxels, calculating voxel weights for each voxel within the at least one block, and determining a block average count and variance for the at least one block.
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20 Claims
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1. A method for processing medical image data, the method comprising:
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receiving a first three-dimensional image comprising a plurality of voxels; reducing a regional trend within the three-dimensional image; computing a semivariogram for a region of interest; defining at least one block of spatially correlated voxels; calculating voxel weights for each voxel within the at least one block; and determining a block average count and variance for the at least one block. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for processing brain image data with increased sensitivity to facilitate comparisons among groups of subjects, the method comprising:
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selecting a plurality of groups of subjects; receiving at least one three-dimensional brain image from each of the subjects, each of three-dimensional brain images comprising a plurality of voxels; and modeling the at least one region of interest of the plurality of three-dimensional brain images, in part, by selecting blocks of voxels so that centers of adjacent blocks are separated by a distance no closer than a range at which voxel counts are uncorrelated. - View Dependent Claims (16, 17, 18)
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19. A computer readable medium having a computer program recorded thereon that causes a computer to perform the steps of:
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receiving a plurality of three-dimensional images, each image comprising a plurality of voxels and each voxel indicating an intensity measurement; reducing a regional trend by spatially fitting a regional mean across a region; computing semivariograms using detrended voxel measurements for each region of interest (ROI) to determine an extent of intervoxel correlation; defining blocks of spatially correlated voxels so that centers of adjacent blocks are no closer than a range parameter computed from the semivariograms; calculating voxels weights within each defined block by solving a kriging system of equations; and determining block average counts and variances for each block by taking the weighted average of voxels within a block. - View Dependent Claims (20)
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Specification