TISSUE REPAIR IMPLANT

• US 20080299172A1
• Filed: 06/03/2008
• Published: 12/04/2008
• Est. Priority Date: 06/04/2007
• Status: Abandoned Application

• Current Assignee: Neville Alleyne, Stuart Young
• Original Assignee: Neville Alleyne, Stuart Young
• Inventors: Alleyne, Neville, Young, Stuart
• Application Number:
  US12/132,557
• Publication Number:
  US 20080299172A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61L 15/325 Collagen
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders

Abstract

An implant is formed from a sheet material and a plurality of microparticles. The sheet may be coated with a mixture of collagen and PMMA beads. The implant may be used to treat many types of defects, including hernias, skin defects, tendon defects, and ulcers. A biocompatible alloplastic mesh implant is stronger and more resistant to infection than typical mesh implants.

Claims

1. An implant comprising:

a sheet material; and

a plurality of microparticles in association with the sheet material.

2. The implant of claim 1, comprising collagen.

3. The implant of claim 1, comprising a fibrous sheet coated with a mixture of collagen and microparticles.

4. The implant of claim 1, wherein the implant is fenestrated.

5. The implant of claim 1, wherein the implant is not fenestrated.

6. The implant of claim 1, wherein the implant is tubular.

7. The implant according to claim 1, wherein the implant is a bandage.

8. The implant according to claim 1, wherein the implant is impregnated with at least one additional therapeutic agent.

9. The implant according to claim 6 wherein the agents are chosen from a group consisting of antibiotics, anesthetics, steroids, growth factors, self-proliferating proteins, mesenchymal cells, mesenchymal native cells, stem cells, topical antibiotics, bone morphogenetic proteins, and recombinant adenoviral vectors.

10. The implant of claim 1, wherein the particles comprise polymethylmethacrylate.

11. The implant of claim 1, wherein the ratio of particles to collagen is 1:

1 to 1;

5.

12. The implant of claim 1, wherein the collagen comprises bovine collagen.

13. The implant of claim 1, wherein the implant comprises 0.3% lidocaine.

14. The implant of claim 9, wherein the particles comprise microspheres.

15. A method of treating an ulcer comprising applying the implant of claim 1 to an ulcer.

16. A method of treating a skin defect comprising applying the implant of claim 1 to a skin defect.

17. A method of treating a hernia comprising applying the implant of claim 1 to a hernia.

18. A method of making an implant comprising coating a sheet material with a substance comprising a plurality of microparticles in a suspending agent.

19. The method of claim 18, wherein the suspending agent comprises collagen.