SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND METHODS FOR PREVENTING RETINAL DYSFUNCTION
First Claim
1. A method of making an ophthalmic composition comprising the steps of:
- (a) combining an organic mixture comprising an alpha-2 adrenergic receptor agonist and a biodegradable polymer, and an aqueous phase, and;
(b) stirring to form biodegradable microspheres capable of releasing the alpha-2 adrenergic receptor agonist upon intravitreal injection of the microspheres.
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Abstract
Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure.
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Citations
5 Claims
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1. A method of making an ophthalmic composition comprising the steps of:
- (a) combining an organic mixture comprising an alpha-2 adrenergic receptor agonist and a biodegradable polymer, and an aqueous phase, and;
(b) stirring to form biodegradable microspheres capable of releasing the alpha-2 adrenergic receptor agonist upon intravitreal injection of the microspheres. - View Dependent Claims (2, 3, 4)
- (a) combining an organic mixture comprising an alpha-2 adrenergic receptor agonist and a biodegradable polymer, and an aqueous phase, and;
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5. A method of making an ophthalmic composition comprising the steps of:
- (a) combining an organic mixture comprising a brimonidine and a biodegradable polylactide polyglycolide copolymer, and an aqueous phase comprising an aliphatic alcohol, and;
(b) stirring the combination to form biodegradable microspheres capable of releasing the brimonidine upon intravitreal injection of the microspheres.
- (a) combining an organic mixture comprising a brimonidine and a biodegradable polylactide polyglycolide copolymer, and an aqueous phase comprising an aliphatic alcohol, and;
Specification