Acid alpha-glucosidase and fragments thereof
2 Assignments
0 Petitions
Accused Products
Abstract
Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
79 Citations
47 Claims
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1-16. -16. (canceled)
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17. A targeted therapeutic fusion protein comprising amino acid residues 70-952 of human acid alpha-glucosidase (GAA) and a peptide tag comprising a deletion of amino acid 2-7 (Δ
- 2-7) of mature human IGF-II.
- View Dependent Claims (20, 29, 30, 31, 32, 47)
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18-19. -19. (canceled)
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21-28. -28. (canceled)
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33-46. -46. (canceled)
Specification