Compositions and methods for diagnosis and treatment for type 2 diabetes
First Claim
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1. A method of diagnosing or identifying type 2 Diabetes, one or more complications related to type 2 Diabetes, or a pre-diabetic condition in a subject, comprising:
- a. measuring an effective amount of one or more T2DBMARKERS or a metabolite thereof in a sample from the subject; and
b. comparing the amount to a reference value, wherein an increase or decrease in the amount of the one or more T2DBMARKERS relative to the reference value indicates that the subject suffers from the type 2 Diabetes, one or more complications related to type 2 Diabetes, or the pre-diabetic condition.
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Abstract
The present invention relates generally to the identification of biological markers associated with an increased risk of developing Diabetes, as well as methods of using such biological markers in diagnosis and prognosis of Diabetes. The biological markers of the invention may indicate new targets for therapy or constitute new therapeutics for the treatment or prevention of Diabetes.
41 Citations
19 Claims
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1. A method of diagnosing or identifying type 2 Diabetes, one or more complications related to type 2 Diabetes, or a pre-diabetic condition in a subject, comprising:
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a. measuring an effective amount of one or more T2DBMARKERS or a metabolite thereof in a sample from the subject; and b. comparing the amount to a reference value, wherein an increase or decrease in the amount of the one or more T2DBMARKERS relative to the reference value indicates that the subject suffers from the type 2 Diabetes, one or more complications related to type 2 Diabetes, or the pre-diabetic condition. - View Dependent Claims (2, 3, 15, 16)
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4. A method for monitoring the progression of type 2 Diabetes, one or more complications relating to type 2 Diabetes, or a pre-diabetic condition in a subject, comprising
a. detecting an effective amount of one or more T2DBMARKERS in a first sample from the subject at a first period of time; -
b. detecting an effective amount of one or more T2DBMARKERS in a second sample from the subject at a second period of time; and c. comparing the amounts of the one or more T2DBMARKERS detected in step (a) to the amount detected in step (b), or to a reference value. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11)
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12. A method of treating a subject diagnosed with or identified as suffering from type 2 Diabetes, one or more complications relating to type 2 Diabetes, or a pre-diabetic condition comprising:
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a. detecting an effective amount of one or more T2DBMARKERS or metabolites thereof present in a first sample from the subject at a first period of time; and b. treating the subject with one or more diabetes-modulating agents until the amounts of the one or more T2DBMARKERS or metabolites thereof return to a reference value measured in one or more subjects at low risk for developing type 2 Diabetes, one or more complications relating to type 2 Diabetes, or a pre-diabetic condition, or a reference value measured in one or more subjects who show improvements in Diabetes risk factors as a result of treatment with the one or more diabetes-modulating agents. - View Dependent Claims (13, 14)
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- 17. An isolated antibody or antigen-binding fragment thereof, comprising a human constant region and an antigen-binding region, wherein the antigen-binding region binds one or more T2DBMARKERS or a metabolite thereof.
Specification