Device for treating hardened lesions and method of use thereof
First Claim
Patent Images
1. A balloon catheter comprising:
- a shaft having a distal end and a proximal end;
an expandable balloon mounted at the distal end of the shaft, the shaft having an inflation lumen extending therethrough in fluid communication with an interior region of the balloon, wherein at least a length of an outer surface of the balloon comprises a working surface adapted to dilate a vessel wall,a cutting device comprising at least one cutting element, the cutting element contacting the outer surface of the balloon when the balloon is in an expanded state, anda composition comprising a bioactive present on at least a portion of the cutting element.
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Abstract
A balloon catheter is provided that may be used to dilate hardened regions of a stenosis on a vessel wall. The balloon catheter is provided with cutting elements that extend along a surface of a balloon. At least one bioactive is present, either on the cutting element, within the interior of the balloon, within the material of the balloon or on an outside surface of the balloon. The bioactive is delivered to the vessel wall upon dilation of the balloon.
155 Citations
20 Claims
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1. A balloon catheter comprising:
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a shaft having a distal end and a proximal end; an expandable balloon mounted at the distal end of the shaft, the shaft having an inflation lumen extending therethrough in fluid communication with an interior region of the balloon, wherein at least a length of an outer surface of the balloon comprises a working surface adapted to dilate a vessel wall, a cutting device comprising at least one cutting element, the cutting element contacting the outer surface of the balloon when the balloon is in an expanded state, and a composition comprising a bioactive present on at least a portion of the cutting element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A balloon catheter comprising:
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a shaft having a distal end and a proximal end; a expandable balloon mounted at the distal end of the shaft, the shaft having an inflation lumen extending therethrough and in fluid communication with an interior region of the balloon, wherein at least a length of an outer surface of the balloon comprises a working surface adapted to dilate a vessel wall, and a cutting device comprising at least one cutting element attached to the outside surface of the balloon, wherein the cutting element comprises at least one channel providing a fluid path between the interior of the balloon and an exterior surface of the balloon. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. A balloon catheter comprising:
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a shaft having a distal end and a proximal end; a expandable balloon mounted at the distal end of the shaft, the shaft having an inflation lumen extending therethrough and in fluid communication with an interior region of the balloon, wherein at least a length of an outer surface of the balloon comprises a working surface adapted to dilate a vessel wall, wherein the balloon comprises at least one pore providing fluid communication between the interior region of the balloon and the outer surface of the balloon, a cutting device comprising at least one cutting element contacting the outer surface of the balloon when the balloon is in an expanded state, and a composition comprising a bioactive present on at least a portion of the cutting element. - View Dependent Claims (17, 18)
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19. A method of delivering a bioactive to a vessel wall, the method comprising:
positioning an expandable balloon portion of a balloon catheter at a site within a vessel, wherein the balloon catheter comprises; a shaft having a distal end and a proximal end; the expandable balloon mounted at the distal end of the shaft, the shaft having an inflation lumen extending therethrough and in fluid communication with an interior region of the balloon, wherein at least a length of an outer surface of the balloon comprises a working surface adapted to dilate a vessel wall, a cutting device comprising at least one cutting element, the cutting element contacting the outer surface of the balloon when the balloon is in an expanded state, and a composition comprising a bioactive reversibly attached to at least a portion of the cutting element; expanding the balloon to cause the cutting element to contact the vessel wall and to dilate the vessel wall, and maintaining contact with the vessel wall for a time sufficient to deliver a therapeutically effective amount of bioactive to the vessel wall. - View Dependent Claims (20)
Specification