SELECTIVE CELL THERAPY FOR THE TREATMENT OF RENAL FAILURE
First Claim
1. An isolated population of cells comprising differentiated peritubular interstitial cells harvested from kidney tissue and passaged in vitro.
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Abstract
Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro. The kidney cells may include peritubular interstitial cells of the kidney, and preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells produce EPO in vivo.
82 Citations
35 Claims
- 1. An isolated population of cells comprising differentiated peritubular interstitial cells harvested from kidney tissue and passaged in vitro.
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8. A method of producing an isolated population of EPO producing cells, said method comprising the steps of:
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providing differentiated kidney cells; and passaging said differentiated kidney cells, wherein said cells produce EPO after said passaging; thereby producing an isolated population of EPO producing cells. - View Dependent Claims (9, 10, 11, 12)
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13. A method of treating a kidney disease resulting in decreased EPO production in a patient in need thereof, said method comprising:
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providing a composition comprising an isolated population of EPO producing cells in a pharmaceutically acceptable carrier; and administering said composition to said patient, whereby said EPO producing cells produce EPO in vivo. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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- 24. An isolated population of cells comprising differentiated human kidney cells harvested from human kidney tissue and passaged in vitro.
Specification