ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES
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Abstract
The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.
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Citations
71 Claims
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1-61. -61. (canceled)
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62. A diagnosis method of dilated cardiomyopathy, which comprises measuring an amount of anti-cardiac troponin I autoantibody.
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63. A method to aid in the assessment of an individual'"'"'s risk of developing a myocardial disorder, the method comprising:
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(a) measuring one or more in vitro antibodies to a cardiac troponin and (b) correlating a value or values obtained in step (a) to the individual'"'"'s risk of developing a myocardial disorder. - View Dependent Claims (64, 65, 66, 67, 68, 69, 70)
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71. A kit comprising a cardiac troponin and auxiliary reagents appropriate for measurement of an antibody to the cardiac troponin.
Specification