EP4 RECEPTOR ANTAGONISTS
0 Assignments
0 Petitions
Accused Products
Abstract
A compound of formula (I):
or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is:
- (i) H or an optionally substituted C1-4 alkyl group; or
- (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group;
- m and n can be 0 or 1, and m+n=1 or 2
- RN is H or optionally substituted C1-4 alkyl
- R3 is either:
- (i) carboxy;
- (ii) a group of formula (II):
- (iii) a group of formula (III):
wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or
- (iv) tetrazol-5-yl.
-
Citations
27 Claims
- 1. A compound of formula (I):
- 15. A method of treating a condition which can be alleviated by antagonism of an EP4 receptor, which method comprises administering to a patient in need of treatment an effective amount of a compound of claim formula (I),
Specification