Method and System for Monitoring Gastrointestinal Function and Physiological Characteristics

• US 20080306355A1
• Filed: 05/08/2008
• Published: 12/11/2008
• Est. Priority Date: 11/20/2006
• Status: Abandoned Application

• Current Assignee: Smithkline Beecham Corporation (Smithkline Beecham PLC)
• Original Assignee: Smithkline Beecham Corporation (Smithkline Beecham PLC)
• Inventors: Walker, Dwight Sherod
• Application Number:
  US12/117,161
• Publication Number:
  US 20080306355A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/6805 Vests
• CPC Class Codes: A61B 7/008 Detecting noise of gastric tract, e.g. caused by voiding

Abstract

A system and method for evaluating gastrointestinal motility and, optionally, other physiological characteristics (e.g., pulse rate) that can be effectively employed to acquire one or more signals associated with acoustic energy (i.e. sound) emanating from an abdominal region of a body and determine at least one gastrointestinal parameter or event based on the acoustic energy signal(s) is described. The gastrointestinal parameter can include a gastrointestinal event, including gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time, or a gastrointestinal system disorder, including reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a migrating motor complex disorder.

Claims

1. A system for monitoring gastrointestinal function of a subject, comprising:

at least one sensor mountable proximate a body region of the subject, said sensor being adapted to sense acoustic energy and generate at least one acoustic energy signal representing said acoustic energy; and

a processing unit adapted to receive said acoustic energy signal, said processing unit being further adapted to process said acoustic energy signal and determine the occurrence of at least one gastrointestinal parameter therefrom.

2. The system of claim 1, wherein said gastrointestinal parameter comprises an event selected from the group consisting of gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.

3. The system of claim 1, wherein said gastrointestinal parameter comprises an event associated with a gastrointestinal system disorder, said gastrointestinal system disorder being selected from the group consisting of reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a mitigating motor complex disorder.

4. The system of claim 1, wherein said sensor generates a plurality of acoustic energy signals representing said acoustic energy.

5. The system of claim 4, wherein said processing unit is adapted to receive and process said plurality of acoustic energy signals and determine the occurrence of at least a first gastrointestinal parameter therefrom.

6. The system of claim 5, wherein said first gastrointestinal parameter comprises gastrointestinal transit time.

7. A system for monitoring gastrointestinal function of a subject, comprising:

at least one acoustic energy sensor mountable proximate a body region of the subject, said acoustic energy sensor being adapted to sense acoustic energy generated by the subject and generate at least one acoustic energy signal representing said acoustic energy;

at least one spatial parameter sensor mountable proximate a body region of the subject, said spatial parameter sensor being adapted to monitor at least one spatial parameter associated with the subject'"'"'s body and generate at least one spatial parameter signal representing said spatial parameter; and

a processing unit adapted to receive said acoustic energy and spatial parameter signals, said processing unit being further adapted to determine the occurrence of at least one gastrointestinal parameter as a function of said acoustic energy and spatial parameter signals.

8. The system of claim 7, wherein said spatial parameter sensor comprises a motion sensor that is adapted to monitor motion of the subject'"'"'s body.

9. The system of claim 8, wherein said spatial parameter comprises said motion of the subject'"'"'s body.

10. The system of claim 7, wherein said spatial parameter sensor comprises an orientation sensor that is adapted to monitor orientation of the subject'"'"'s body.

11. The system of claim 10, wherein said spatial parameter comprises said orientation of the subject'"'"'s body.

12. The system of claim 7, wherein said gastrointestinal parameter comprises an event selected from the group consisting of gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.

13. The system of claim 7, wherein said gastrointestinal parameter comprises an event associated with a gastrointestinal system disorder, said gastrointestinal system disorder being selected from the group consisting of reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a mitigating motor complex disorder.

14. A system for monitoring gastrointestinal function and physiological characteristics, comprising:

at least one acoustic energy sensor mountable proximate a body region of a subject, said acoustic energy sensor being adapted to sense acoustic energy representing a gastrointestinal sound generated by said subject and generate at least a first acoustic energy signal representing said acoustic energy;

at least one physiological sensor mountable proximate a body region of said subject, said physiological sensor being adapted to sense a physiological characteristic associated with said subject and generate at least a first physiological characteristic signal representing said physiological characteristic; and

a processing unit adapted to receive said first acoustic energy and physiological characteristic signals, said processing unit being further adapted to process said first acoustic energy signal and determine the occurrence of at least one gastrointestinal parameter therefrom.

15. The system of claim 14, wherein said gastrointestinal parameter comprises an event selected from the group consisting of gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.

16. The system of claim 14, wherein said gastrointestinal parameter comprises an event associated with a gastrointestinal system disorder, said gastrointestinal system disorder being selected from the group consisting of reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a mitigating motor complex disorder.

17. The system of claim 14, wherein said physiological characteristic comprises a physiological characteristic selected from the group consisting of pulse rate, blood pressure, blood gas saturation, respiration rate, skin temperature, and electrical impulses associated with heart function.

18. A system for monitoring gastrointestinal function and physiological characteristics, comprising:

at least one acoustic energy sensor mountable proximate a body region of a subject, said acoustic energy sensor being adapted to sense acoustic energy representing a gastrointestinal sound generated by said subject and generate at least one acoustic energy signal representing said acoustic energy;

at least one spatial parameter sensor mountable proximate a body region of the subject, said spatial parameter sensor being adapted to monitor at least one spatial parameter associated with the subject'"'"'s body and generate at least one spatial parameter signal representing said spatial parameter;

at least one physiological sensor mountable proximate a body region of said subject, said physiological sensor being adapted to sense a physiological characteristic associated with said subject and generate at least one physiological characteristic signal representing said physiological characteristic; and

a processing unit adapted to receive said acoustic energy, spatial parameter and physiological characteristic signals, said processing unit being further adapted to determine the occurrence of at least one gastrointestinal parameter as a function of said acoustic energy and spatial parameter signals.

19. The system of claim 18, wherein said spatial parameter sensor comprises a motion sensor that is adapted to monitor motion of the subject'"'"'s body.

20. The system of claim 19, wherein said spatial parameter comprises said motion of the subject'"'"'s body.

21. The system of claim 18, wherein said spatial parameter sensor comprises an orientation sensor that is adapted to monitor orientation of the subject'"'"'s body.

22. The system of claim 21, wherein said spatial parameter comprises said orientation of the subject'"'"'s body.

23. The system of claim 18, wherein said gastrointestinal parameter comprises an event selected from the group consisting of gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.

24. The system of claim 18, wherein said gastrointestinal parameter comprises an event associated with a gastrointestinal system disorder, said gastrointestinal system disorder being selected from the group consisting of reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a mitigating motor complex disorder.

25. The system of claim 18, wherein said physiological characteristic comprises a physiological characteristic selected from the group consisting of pulse rate, blood pressure, blood gas saturation, respiration rate, skin temperature, and electrical impulses associated with heart function.

26. A method of determining a gastrointestinal parameter associated with a subject, comprising the steps of:

sensing acoustic energy generated by the subject'"'"'s gastrointestinal system and generating an acoustic energy signal representing said acoustic energy;

sensing at least one spatial parameter associated with the subject and generating a spatial parameter signal representing said spatial parameter; and

determining at least one gastrointestinal parameter as a function of said acoustic energy and spatial parameter signals.

27. The method of claim 26, further comprising utilizing said spatial parameter signal to adjust said sensing of acoustic energy.

28. The method of claim 26, wherein said spatial parameter comprises said motion of the subject'"'"'s body.

29. The method of claim 26, wherein said spatial parameter comprises said orientation of the subject'"'"'s body.

30. The system of claim 26, wherein said gastrointestinal parameter comprises an event selected from the group consisting of gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.

31. The system of claim 26, wherein said gastrointestinal parameter comprises an event associated with a gastrointestinal system disorder, said gastrointestinal system disorder being selected from the group consisting of reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a mitigating motor complex disorder.

32. A method of determining a gastrointestinal parameter associated with a subject, comprising the steps of:

sensing acoustic energy generated by the subject'"'"'s gastrointestinal system and generating an acoustic energy signal representing said acoustic energy;

sensing at least one spatial parameter associated with the subject and generating a spatial parameter signal representing said spatial parameter;

sensing at least one physiological characteristic associated with the subject and generating at least one physiological characteristic signal representing said physiological characteristic; and

determining at least one gastrointestinal parameter as a function of said acoustic energy and spatial parameter signals.

33. The method of claim 32, further comprising utilizing said spatial parameter signal to adjust said sensing of acoustic energy.

34. The method of claim 32, wherein said spatial parameter comprises said motion of the subject'"'"'s body.

35. The method of claim 32, wherein said spatial parameter comprises said orientation of the subject'"'"'s body.

36. The method of claim 32, wherein said gastrointestinal parameter comprises an event selected from the group consisting of gastrointestinal mixing, emptying, contraction and propulsion, and gastrointestinal transit time.

37. The method of claim 32, wherein said gastrointestinal parameter comprises an event associated with a gastrointestinal system disorder, said gastrointestinal system disorder being selected from the group consisting of reflux disease, irritable bowel disease, ulcerative colitis, constipation, diarrhea, and a mitigating motor complex disorder.

38. The method of claim 32, wherein said physiological characteristic comprises a physiological characteristic selected from the group consisting of pulse rate, blood pressure, blood gas saturation, respiration rate, skin temperature, and electrical impulses associated with heart function.

39. A method of monitoring gastrointestinal function and physiological characteristics of multiple subjects, comprising the steps of:

sensing first acoustic energy generated by a first subject'"'"'s gastrointestinal system and generating a first acoustic energy signal representing said first acoustic energy;

sensing a first physiological characteristic associated with said first subject;

sensing a second physiological characteristic associated with a second subject;

determining at least one gastrointestinal parameter associated with said first subject as a function of said first acoustic energy signal.

40. The method of claim 39, wherein said second subject comprises a fetus of said first subject.