METHOD AND SYSTEM FOR DETERMINING VITALITY, HEALING AND CONDITION OF TISSUE OR ORGAN FOR SURGERY

• US 20080306402A1
• Filed: 08/19/2008
• Published: 12/11/2008
• Est. Priority Date: 09/25/2006
• Status: Abandoned Application

• Current Assignee: Michaeal G. Singer
• Original Assignee: Michaeal G. Singer
• Inventors: SINGER, MICHAEAL G.
• Application Number:
  US12/194,502
• Publication Number:
  US 20080306402A1
• Time in Patent Office: Days
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/6825 Hand
• CPC Class Codes: A61B 5/6829 Foot or ankle

Abstract

A method of organ and tissue vitality assessment for surgery, including subjecting the organ or tissue to bioelectrical impedance analysis;

taking initial and serial measurements of resistance, reactance, capacitance, phase angle, impedance or any value derived therefrom; and

tracking the initial and serial measurements to establish vitality, healing, and condition of the organ or tissue for surgery.

Claims

1. A method of organ and tissue vitality assessment for surgery, comprising the steps of:

subjecting the organ or tissue to bioelectrical impedance analysis;

taking initial and serial measurements of resistance, reactance, capacitance, phase angle, impedance or any value derived therefrom; and

tracking said initial and serial measurements to establish vitality, healing, and condition of said organ or tissue for surgery.

2. The method according to claim 1, including the step of:

utilizing a modified bioelectrical impedance analysis for composition analysis to assess the health of cells of said organ and tissue by the measured reactance thereof.

3. A method according to claim 1, wherein upon harvesting, processing, preserving, treating or transporting said organ or tissue from the donor or source, including the steps of:

placing signal introduction electrodes on opposite lateral peripheral borders of said organ or tissue;

placing signal detection electrodes at superior and inferior borders of said organ or tissue for a first part of an initial measurement;

measuring and recording first values of resistance and reactance and calculating the phase angle of said organ or tissue in said initial measurement;

then placing said signal introduction electrodes on said superior and said inferior borders of said organ or tissue;

placing said signal detection electrodes on said opposite lateral borders of said organ or tissue;

measuring and recording second values of said resistance and said reactance and calculating the phase angle of said organ or tissue; and

comparing said first and second values to normal values to assess vitality.

4. A method according to claim 2, wherein upon arrival of said organ or tissue at the location of the recipient including the steps of:

placing signal introduction electrodes on opposite lateral peripheral borders of said organ or tissue;

placing signal detection electrodes at superior and inferior borders of said organ or tissue for a first part of an initial measurement of said organ or tissue;

measuring and recording first values of resistance and reactance and calculating the phase angle of said organ or tissue in said initial measurement;

then placing said signal introduction electrodes on said superior and said inferior borders of said organ or tissue;

placing said signal detection electrodes on said opposite lateral borders of said organ or tissue;

measuring and recording second values of said resistance and said reactance and calculating the phase angle of said organ or tissue; and

comparing said first and second values to normal values to assess vitality of said organ or tissue.

5. A method according to claim 3, wherein prior to implantation of said organ or tissue into the recipient including the following additional steps:

again placing said signal introduction electrodes on said opposite lateral peripheral borders of said organ or tissue;

again placing said signal detection electrodes at said superior and said inferior borders of said organ or tissue;

measuring and recording third values of resistance and reactance and calculating the phase angle of said organ or tissue;

then again placing said signal introduction electrodes on said superior and said inferior borders of said organ or tissue;

again placing said signal detection electrodes on said opposite lateral borders of said organ or tissue;

measuring and recording fourth values of said resistance and said reactance of said organ or tissue; and

comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of organ or tissue vitality.

6. A method according to claim 4, including the following additional steps:

again placing said signal introduction electrodes on said opposite lateral peripheral borders of said organ or tissue;

again placing said signal detection electrodes at said superior and said inferior borders of said organ or tissue;

measuring and recording third values of resistance and reactance and calculating the phase angle of said organ or tissue;

then again placing said signal introduction electrodes on said superior and said inferior borders of said organ or tissue;

again placing said signal detection electrodes on said opposite lateral borders of said organ or tissue;

measuring and recording fourth values of said resistance and said reactance and calculating the phase angle of said organ; and

comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of organ or tissue vitality.

8. A method according to claim 1, including:

harvesting said organ or tissue from a first species of biological entity; and

implanting said organ or tissue in a different species of biological entity.

9. A method according to claim 1, wherein:

said measured values of resistance and reactance and the calculation of phase angle changes will be compared to their previous values and considered in rate of change either increase or decrease the assessment of vitality.

10. A method according to claim 1, including the steps of:

comparing and assessing homogeneity within heterogeneous populations based upon comparative values of calculated phase angles.

11. A method according to claim 1, wherein:

severity, criticality or burden of an adverse condition is based upon calculated phase angle value in that a higher value indicates a less severe, critical or burden of adversity and a lower value indicates a greater severity, criticality or burden of adversity.

12. A method according to claim 11, wherein:

resources allocated or required to manage said adverse condition are based upon said calculated phase angle value in that the lower phase angle value entity requires greater resources than that of an entity with a greater phase angle value.

13. A method according to claim 1, wherein:

the vitality of said organ or tissue will have different levels of vitality based upon its measured resistance, reactance and calculated phase angle which, while it may not be optimal, will be sufficient for its purpose and may further be used to classify its use for a corresponding recipient with the matching of a higher phase angle value to the recipient with a lower phase angle value and conversely the matching of a organ or tissue with a lower phase angle value with a recipient of a higher phase angle value.

14. A method according to claim 1, including the steps of:

assessing of any trauma, operative site or transplant site, recipient and/or donor area to assess and monitor healing, perfusion, infection, inflammation I by comparing measured values of impedance (bioelectrical) to previous values and improvements as in increasing Pa, Xc, Cap and Par Cap or while monitoring R and having it return to healthy values, or by seeing R decrease from baseline indicating the accumulation of extracellular fluids, decreasing Xc, Cap, Pa and or Par Cap.

15. A method according to claim 3, including the steps of:

assessing of any trauma, operative site or transplant site, recipient and/or donor area to assess and monitor healing, perfusion, infection, inflammation I by comparing measured values of impedance (bioelectrical) to previous values and improvements as in increasing Pa, Xc, Cap and Par Cap or while monitoring R and having it return to healthy values, or by seeing R decrease from baseline indicating the accumulation of extracellular fluids, decreasing Xc, Cap, Pa and or Par Cap.

16. A method according to claim 4, including the steps of:

assessing of any trauma, operative site or transplant site, recipient and/or donor area to assess and monitor healing, perfusion, infection, inflammation I by comparing measured values of impedance (bioelectrical) to previous values and improvements as in increasing Pa, Xc, Cap and Par Cap or while monitoring R and having it return to healthy values, or by seeing R decrease from baseline indicating the accumulation of extracellular fluids, decreasing Xc, Cap, Pa and or Par Cap.

17. A method according to claim 5, including the steps of:

assessing of any trauma, operative site or transplant site, recipient and/or donor area to assess and monitor healing, perfusion, infection, inflammation I by comparing measured values of impedance (bioelectrical) to previous values and improvements as in increasing Pa, Xc, Cap and Par Cap or while monitoring R and having it return to healthy values, or by seeing R decrease from baseline indicating the accumulation of extracellular fluids, decreasing Xc, Cap, Pa and or Par Cap.

18. A method according to claim 6, including the steps of:

assessing of any trauma, operative site or transplant site, recipient and/or donor area to assess and monitor healing, perfusion, infection, inflammation I by comparing measured values of impedance (bioelectrical) to previous values and improvements as in increasing Pa, Xc, Cap and Par Cap or while monitoring R and having it return to healthy values, or by seeing R decrease from baseline indicating the accumulation of extracellular fluids, decreasing Xc, Cap, Pa and or Par Cap.

20. A method according to claim 13, including the steps of:

assessing of any trauma, operative site or transplant site, recipient and/or donor area to assess and monitor healing, perfusion, infection, inflammation I by comparing measured values of impedance (bioelectrical) to previous values and improvements as in increasing Pa, Xc, Cap and Par Cap or while monitoring R and having it return to healthy values, or by seeing R decrease from baseline indicating the accumulation of extracellular fluids, decreasing Xc, Cap, Pa and or Par Cap.

19. A method according to claim 7, including the steps of:

assessing of any trauma, operative site or transplant site, recipient and/or donor area to assess and monitor healing, perfusion, infection, inflammation I by comparing measured values of impedance (bioelectrical) to previous values and improvements as in increasing Pa, Xc, Cap and Par Cap or while monitoring R and having it return to healthy values, or by seeing R decrease from baseline indicating the accumulation of extracellular fluids, decreasing Xc, Cap, Pa and or Par Cap.