ACCURATE METERING SYSTEM

• US 20080308580A1
• Filed: 11/16/2006
• Published: 12/18/2008
• Est. Priority Date: 02/14/2006
• Status: Active Grant

• Current Assignee: Efield Innovations, LLC
• Original Assignee: Ventaira Pharmaceuticals Inc. (Battelle Memorial Institute)
• Inventors: Mcveety, Bruce D., Proicou, George C., Gaydos, Peter A., Lipp, Brian A.
• Granted Patent: US 7,959,609 B2
• Time in Patent Office: Days
• US Class Current: 222/333
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2005/31588 electrically driven
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2205/106 reciprocating
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3372 Temperature compensation
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/702 automatically during use
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31556 : Accuracy improving means
• CPC Class Codes: A61M 5/31573 : Accuracy improving means
• CPC Class Codes: B05C 17/0103 : with electrically actuated piston or the like
• CPC Class Codes: G01F 11/029 : provided with electric controlling means G01F11/022 and G01F11/024 take precedence

Abstract

The present invention is directed to metering devices, systems, and methods that mitigate differential thermal expansion/contraction for the efficient, accurate, and reproducible metered delivery of fluids. The present invention allows the net fluid volume and a plunger location within a fluid dispensing container to automatically adjust under the influence of differential thermal expansion/contraction between the fluid and the fluid dispensing container that the fluid is contained within. Further, the present invention allows the metering system drive to sense the adjusted plunger location and allows the metering system drive to re-zero itself to produce an accurate volumetric delivery of fluid from the fluid dispensing container. The metering system includes means for controlling the travel of the metering system drive, and hence the travel of the plunger into the fluid dispensing container, for delivering accurate/precise amounts of the fluid from the fluid dispensing container. The metering system may also mitigate dead volume in the metering system.

Claims

1. An accurate metering device comprising:

a fluid dispensing container containing a fluid to be dispensed, wherein said fluid dispensing container comprises a reducible volume;

a movable portion that is free to move in response to changes in fluid volume of said fluid contained within said fluid dispensing container;

a net fluid volume, wherein said net fluid volume within said fluid dispensing container changes as said movable portion moves with respect to said fluid dispensing container;

a metering drive that selectively contacts said movable portion;

a starting point comprising a point wherein said metering drive is re-zeroed; and

wherein said metering drive is actuated a known amount from said starting point thus moving said movable portion and reducing said reducible volume of said fluid dispensing container and causing a specific quantity of said fluid to be dispensed from said fluid dispensing container.

2. The metering device of claim 1, wherein said starting point comprising a point wherein said metering drive engages said movable portion of said fluid dispensing container.

3. The metering device of claim 1, wherein said starting point comprising a point when fluid deliver commences.

4. The metering device of claim 1, wherein said starting point comprising a point when said fluid dispensing container is primed.

5. The metering device of claim 1, wherein said starting point comprising a point wherein said metering drive becomes fully loaded.

6. The metering device of claim 1, wherein said accurate metering device mitigates differential thermal expansion and/or contraction between said fluid dispensing container and said fluid contained within said fluid dispensing container by allowing said movable portion to move in response to differential thermal expansion and/or contraction between said fluid dispensing container and said fluid contained within said fluid dispensing container.

7. The metering device of claim 6, further comprising a sliding force, wherein said sliding force is a force required to ensure that said plunger moves before a cracking pressure of an outlet valve during differential thermal expansion and a force required to ensure that the plunger moves with ambient atmospheric pressure during differential thermal contraction.

8. The metering device of claim 1, wherein said accurate metering device mitigates differential thermal expansion between said fluid dispensing container and said fluid contained within said fluid dispensing container by allowing said movable portion to move in response to differential thermal expansion between said fluid dispensing container and said fluid contained within said fluid dispensing container.

9. The metering device of claim 8, further comprising an expansion sliding force, wherein said expansion sliding force is a force low enough to ensure that said movable portion moves before leakage from an outlet during differential thermal expansion.

10. The metering device of claim 1, wherein said accurate metering device mitigates differential thermal contraction between said fluid dispensing container and said fluid contained within said fluid dispensing container by allowing said movable portion to move in response to differential thermal contraction between said fluid dispensing container and said fluid contained within said fluid dispensing container.

11. The metering device of claim 10, further comprising a contraction sliding force, wherein said contraction sliding force is a force low enough to ensure that said movable portion moves with ambient atmospheric pressure during differential thermal contraction.

12. The metering device of claim 1, wherein said movable portion of said fluid dispensing container moves relative to said fluid dispensing container in response to an expansion of said net fluid volume in said fluid dispensing container caused by a change in temperature and/or moves relative to said fluid dispensing container in response to a contraction of said net fluid volume in said fluid dispensing container cause by an opposite change in temperature.

13. The metering device of claim 1, wherein said metering drive that selectively contacts said movable portion further comprises:

an engaged position wherein said metering drive is in contact with said movable portion of said fluid dispensing container; and

a disengaged position wherein said metering drive is not in contact with said movable portion of said fluid dispensing container.

14. The metering device of claim 1, wherein said metering drive further comprises:

a motor;

an output shaft of said motor;

a gear train coupled to said output shaft; and

a lead screw coupled to said gear train, wherein said lead screw selectively contacts said movable portion of said fluid dispensing container.

15. The metering device of claim 14, wherein said metering drive can be backed off of and disengaged from said movable portion of said fluid dispensing container.

16. The metering device of claim 15, wherein said motor further comprises:

a reversible motor;

wherein said motor is run in a forward direction to cause said metering drive to engage and push said movable portion of said fluid dispensing container forward to reduce said net fluid volume; and

wherein said motor is run in a reverse direction to back said metering drive off of said movable portion of said fluid dispensing container.

17. The metering device of claim 15, wherein said metering drive is backed off a distance sufficient to allow said movable portion of said fluid dispensing container to expand through a pre-determined temperature range that said metering device is expected to operate in.

18. The metering device of claim 14, wherein said metering drive can be advanced at multiple and/or variable speeds.

19. The metering device of claim 18, further comprises:

a seeking speed and a delivery speed;

wherein said metering drive is advanced at said seeking speed toward said movable portion of said fluid dispensing container until said metering drive contacts said movable portion; and

wherein said metering drive is advanced at said delivery speed after said metering drive contacts said movable portion of said fluid dispensing container.

20. The metering device of claim 19, wherein said motor further comprises a multiple and/or variable speed motor.

21. The metering device of claim 1, further comprising a sensor that senses when said metering drive contacts said movable portion.

22. The metering device of claim 21, wherein said sensor further comprises a switch type sensor.

23. The metering device of claim 21, wherein said sensor further comprises an electric circuit and algorithm that monitors a current of a motor that drives said metering drive, wherein said starting point is determined to be a point when the motor becomes loaded.

24. The metering device of claim 1, wherein said specific quantity of said fluid from said fluid dispensing container further comprises a dose, wherein said fluid dispensing container comprises one or more doses, and wherein said metering device delivers substantially accurate and substantially reproducible doses.

25. The metering device of claim 1, wherein said specific quantity of said fluid from said fluid dispensing container further comprises a set volume of said fluid.

26. The metering device of claim 1, further comprising:

an outlet opening in said fluid dispensing container for allowing fluid to exit said fluid dispensing container; and

a valve in fluid communication with said outlet opening, wherein said valve prevents fluid from exiting said fluid dispensing container until sufficient force is applied to said movable portion of said fluid dispensing container to overcome a closing force on said valve.

27. The metering device of claim 26, wherein a force required to move said movable portion of said fluid dispensing container in response to differential thermal expansion is less than said opening force on said valve.

28. The metering device of claim 1, wherein a force required to move said movable portion of said fluid dispensing container in response to differential thermal contraction is less than available atmospheric pressure.

29. The metering device of claim 26, further comprising:

a fluid passageway in fluid communication with said outlet opening of said fluid dispensing container; and

a nozzle in fluid communication with said fluid passageway, wherein said nozzle dispenses said fluid as an aerosol.

30. The metering device of claim 1, further comprising:

a seal between said movable portion of said fluid dispensing container and a rigid portion of said fluid dispensing container;

wherein said seal allows said movable portion of said fluid dispensing container to move relative to said rigid portion of said fluid dispensing container, wherein said seal substantially prevents the ingress of contaminants into said fluid dispensing container and/or the egress of fluid out of said fluid dispensing container at an interface between said fluid dispensing container and said movable portion.

31. The metering device of claim 1, wherein said metering drive further comprises:

a gear having a plurality of teeth and an axis of rotation;

a lead screw extending from one side of said gear along said axis of rotation, wherein said lead screw is threadedly engaged with a mating thread fixed from rotation on said gear; and

wherein said rotation of said gear causes axial movement of said lead screw.

32. The metering device of claim 31, further comprising:

a encoder disk driven by said gear to measure a movement of said metering drive;

a plurality of windows disposed annularly around said encoder disk.

33. The metering device of claim 32, further comprising:

a sensor for sensing a rotation of said encoder disk by monitoring said plurality of windows;

wherein each of said plurality of windows represents a set volume of said fluid.

34. The metering device of claim 1, wherein said metering system further comprises a syringe-based metering system, and wherein:

said fluid dispensing container further comprises a syringe;

said movable portion further comprises a piston plunger slidably disposed within said syringe; and

said metering drive further comprises a lead screw;

wherein said lead screw allows said plunger to move axially within said syringe in response to differential thermal expansion and/or contract between said syringe and said fluid within said syringe when the metering device is not in use; and

wherein said lead screw locates an axial position of said plunger within said syringe before dispensing said fluid from said syringe.

35. The metering device of claim 1, wherein said fluid in said fluid dispensing container further comprises a drug formulated in ethanol solution.

36. The metering device of claim 1, further comprising a motor, wherein said metering drive is coupled to said motor;

said metering drive further comprising a mating surface and tip geometry;

said movable portion further comprising a mating surface and shape that correspond to the mating surface and tip geometry of said metering drive; and

wherein said mating surfaces and tip geometry facilitate sensing of said metering drive contacting and engaging said movable portion by amplifying a change in motor current of said motor.

37. The metering device of claim 36, said metering drive further comprises a lead screw, said mating surface and tip geometry at a distal end of said lead screw further comprises:

a cylindrical portion;

a tapered shoulder;

said movable portion further comprising a plunger, said mating surface and shape at a rear end of said plunger further comprises;

an opening for receiving said cylindrical portion of said lead screw; and

a tapered surface that contacts said tapered shoulder of said lead screw;

wherein said cylindrical portion and said opening provide a piloting function to ensure good contact and said tapered shoulder and said tapered surface form a friction contact between said lead screw and said plunger.

38. A syringe-based metering system that mitigates differential thermal expansion, said syringe-based metering system comprising:

a syringe defining an interior volume for containing a fluid;

an outlet opening at a front end of said syringe;

a piston-type plunger slidably disposed within said syringe through an opening in a rear end of said syringe;

a net fluid volume defined by a location of said plunger within said syringe, wherein said net fluid volume changes with movement of said plunger within said syringe; and

a metering drive that selectively engages and disengages said plunger, wherein said metering drive engages said plunger through said opening in said rear end of said syringe and is advanced to expel fluid from said syringe, wherein said metering drive disengages said plunger by being backed off of said plunger when said syringe-based metering system is not in use;

wherein said plunger is permitted to slide axially within said syringe to mitigate differential thermal expansion and/or contraction between said syringe and said fluid contained within said syringe.

39. The syringe-based metering system of claim 38, wherein said metering drive further comprises an operating and a non-operating position;

wherein said metering drive is not in contact with said plunger when said syringe-based metering system is not operating;

wherein said metering drive seeks and locates said plunger when said syringe-based metering system is activated; and

wherein said metering drive is in contact with and pushes said plunger forward into said syringe when said syringe-based metering system is operating, wherein said net fluid volume is reduced as said metering drive moves said plunger into said syringe and fluid is expelled through said outlet opening.

40. The syringe-based metering system of claim 38, further comprising:

a clearance between said metering drive and said plunger when said syringe-based metering system is not operating;

wherein said clearance allows said plunger to slide rearward in said syringe in response to differential thermal expansion between said syringe and said fluid contained within said syringe.

41. The syringe-based metering system of claim 38, further comprising:

a valve in fluid communication with said outlet opening of said syringe; and

a differential thermal expansion sliding force, wherein said differential thermal expansion sliding force is the force required to cause said plunger to slide rearward in response to differential thermal expansion resulting from an increase in temperature;

wherein said differential thermal expansion sliding force is less than a cracking pressure of said valve.

42. The syringe-based metering system of claim 41, wherein said valve substantially prevents leakage of fluid from said syringe until said metering drive is activated and pushes said plunger forward a sufficient distance to force said fluid out of said syringe into said valve and overcome said cracking pressure of said valve.

43. The syringe-based metering system of claim 38, further comprising:

a differential thermal contraction sliding force, wherein said differential thermal contraction sliding force is the force required to cause said plunger to slide forward in response to differential thermal contraction resulting from a decrease in temperature.

44. The syringe-based metering system of claim 43, wherein said differential thermal contraction sliding force is less than available atmospheric pressure.

45. The syringe-based metering system of claim 38, further comprising:

an interference fit between said syringe and said plunger;

an actuation sliding force, wherein said actuation sliding force is the force required to overcome a friction force of said interference fit between said syringe and said plunger, and wherein said actuation sliding force causes said plunger to slide forward in to said syringe; and

wherein said actuation sliding force is equal to a force required to overcome friction between said plunger and an inner wall of said syringe plus a resistive force on said plunger created by a pressure of said fluid in said syringe.

46. The syringe-based metering system of claim 38, further comprising:

a seal formed between said syringe and said plunger,

wherein said seal substantially prevents fluid from leaking out of an interior of said syringe between said syringe and said plunger, and

wherein said plunger and seal seals said fluid within said syringe.

47. The syringe-based metering system of claim 46, further comprising a sealing force, wherein:

said sealing force is the force required to substantially prevent said fluid from leaking between said syringe and said plunger, and

wherein said sealing force multiplied by a coefficient of friction for a given material pair is less than an actuation sliding force exerted by said metering drive to push said plunger forward.

48. The syringe-based metering system of claim 46, further comprising a sealing force, wherein:

said sealing force is the force required to substantially prevent said fluid from leaking between said syringe and said plunger,

said sealing force multiplied by a coefficient of friction for a given material pair is less than a differential thermal expansion sliding force, which is the force required to cause said plunger to slide rearward in response to differential thermal expansion resulting from an increase in temperature; and

said sealing force multiplied by a coefficient of friction for a given material pair is less than a differential thermal contraction sliding force, wherein said differential thermal contraction sliding force is the force required to cause said plunger to slide forward in response to differential thermal contraction resulting from a decrease in temperature.

49. A method of mitigating the effects of differential thermal expansion in a metering system to ensure accurate metering of a fluid, said method comprising:

containing a fluid to be dispensed in a fluid dispensing container having a reducible volume;

providing a movable portion that can slide within said fluid dispensing container to reduce said reducible volume causing said fluid to be dispensed;

providing a metering drive that can selectively engage said movable portion to move said movable portion causing said reducible volume of said fluid dispensing container to be reduced in an operating mode; and

mitigating the effects of differential thermal expansion by allowing said metering drive to be backed off of said movable portion in a non-operating mode to provide a clearance between said movable portion and said metering drive.

50. The method of claim 49, said method further comprising:

mitigating the effect of differential thermal expansion and/or contraction between said fluid dispensing container and said fluid contained within said fluid dispensing container by allowing said movable portion to move back and forth in response to an expanding and/or contracting fluid volume of said fluid contained within said fluid dispensing container caused by an increasing and/or decreasing temperature.

51. The method of claim 49, said method further comprising:

mitigating the effect of differential thermal contraction between said fluid dispensing container and said fluid contained within said fluid dispensing container by allowing said movable portion to move forward in response to a contracting fluid volume of said fluid contained within said fluid dispensing container caused by a decreasing temperature.

52. The method of claim 49, said method further comprising:

mitigating the effect of differential thermal expansion between said fluid dispensing container and said fluid contained within said fluid dispensing container by allowing said movable portion to move backward in response to a expanding fluid volume of said fluid contained within said fluid dispensing container caused by an increasing temperature.

53. The method of claim 49, said method further comprising:

seeking said movable portion with said metering drive;

sensing engagement of said metering drive with said movable portion;

designating a starting point for metering of said fluid at one of;

said engagement of said metering drive with said movable portion, movement of said movable portion by said metering drive, a loaded condition of said metering drive, and commencement of fluid delivery; and

metering a dose of fluid from said starting point.

54. The method of claim 53, said method further comprising:

filling a nozzle dead volume with fluid during said step of seeking and before designation of said starting point.

55. The method of claim 49, said method further comprising:

sensing a movement of said metering drive; and

correlating said movement of said metering drive to said set volume of fluid to deliver a set volume of fluid from said fluid dispensing container.

56. The method of claim 55, said step of sensing a movement of said metering drive further comprises:

engaging an encoder disk with a gear train driving said metering drive; and

counting one or more windows in said encoder disk, wherein each of said one or more windows represents a set volume of fluid.

57. The method of claim 49, said method further comprising:

providing an interference fit between said movable portion and said fluid dispensing container, wherein said interference fit creates a friction force between said movable portion and said fluid dispensing container;

designing said metering system to have a differential thermal expansion sliding force required to cause said movable portion to slide rearward within said fluid dispensing container in response to an increasing temperature, wherein said differential thermal expansion sliding force is greater than said friction force between said movable portion and said fluid dispensing container;

designing said metering system to have a differential thermal contraction sliding force required to cause said movable portion to slide forward within said fluid dispensing container in response to a decreasing temperature, wherein said differential thermal contraction sliding force is greater than said friction force between said movable portion and said fluid dispensing container plus a resistive force on said movable portion created by a pressure of said fluid in said fluid dispensing container acting on said movable portion.

58. The method of claim 57, said method further comprising:

designing said metering system to have an actuation sliding force required to cause said movable portion to slide within said fluid dispensing container when said metering system is actuated, wherein said actuation sliding force is greater than said friction force between said movable portion and said fluid dispensing container plus a resistive force on said movable portion created by a pressure of said fluid in said fluid dispensing container acting on said movable portion.

59. The method of claim 57, said method further comprising:

providing an interference fit between said movable portion and said fluid dispensing container; and

sealing said fluid within said fluid dispensing container using said interference fit.

60. The method of claim 49, said method further comprising sealing an interface between said movable portion and said fluid dispensing container.