Analytical devices with integrated desiccant

• US 20080311002A1
• Filed: 04/17/2008
• Published: 12/18/2008
• Est. Priority Date: 04/20/2007
• Status: Active Grant

• Current Assignee: Quidel Corporation
• Original Assignee: Quidel Corporation
• Inventors: Kirby, Kevin J., Dennison, Sarah
• Granted Patent: US 8,435,461 B2
• Time in Patent Office: Days
• US Class Current: 422/68.1
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2300/105 using desiccants
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
• CPC Class Codes: G01N 33/56938 Staphylococcus
• CPC Class Codes: G01N 33/56983 Viruses

Abstract

An analytical device for performing an assay to determine the presence or approximate quantity of at least one analyte in a liquid sample is described. The device is manufactured to include an integrated desiccant within at least a test strip of the device. Addition of an integrated desiccant within the device improves signal to noise ratio, eases the manufacturing process, and saves in cost of production of the device.

Claims

1. A device for detection of an analyte in a biological sample, comprising an analytical test strip having a desiccant integrated therein.

2. The device of claim 1, wherein the desiccant is comprised of a material selected from the group consisting of molecular sieves and silica gel.

3. The device of claim 1, wherein the integrated desiccant is secured to the test strip by an adhesive.

4. The device of claim 1, wherein the integrated desiccant is secured to the test strip by laminating a film containing desiccant to more or more regions of the analytical test strip.

5. The device of claim 1, wherein the integrated desiccant is secured to the analytical test strip by a mechanical means.

6. The device of claim 1, wherein the analytical test strip is in the form of a dipstick.

7. The device of claim 1, wherein the analytical test strip comprises one or more of a sample receiving pad, a label pad, a porous pad, and an absorbent pad, and wherein the integrated desiccant is in physical contact with said one or more pads.

8. The device of claim 1, wherein the analytical test strip comprises an absorbent pad, and wherein the integrated desiccant is adjacent said absorbent pad.

9. The device of claim 8, wherein said integrated desiccant is in physical contact with said absorbent pad.

10. The device of claim 1, wherein said desiccant is a film comprised of a polymer having a desiccant dispersed therein.