ADHERENCE INHIBITOR DIRECTED TO AND METHOD OF MAKING AND USING

• US 20080311129A1
• Filed: 11/01/2007
• Published: 12/18/2008
• Est. Priority Date: 11/02/2006
• Status: Abandoned Application

• Current Assignee: Camas Incorporated
• Original Assignee: Camas Incorporated
• Inventors: Mitteness, Bradley M., Nash, Peter, O'Rourke, Michael
• Application Number:
  US11/933,778
• Publication Number:
  US 20080311129A1
• Time in Patent Office: Days
• US Class Current: 424/165.1
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07K 16/1275 from Streptococcus (G)
• CPC Class Codes: C07K 2317/23 from birds

Abstract

A method for the production of antibodies or microbial adherents administers is disclosed. The antibodies or microbial adherents inhibitors are administered to a patient suffering from strep throat to substantially prevent the adherents of colony-forming immunogens or haptens in the throat of the patient. Application of the antibodies should decrease the colonization of the oropharnyx, and therefore decrease symptoms of the sore inflamed throat and ultimately decrease the need for antibiotics.

Claims

1. A method of production of an adherence inhibitor for administration to humans to control the colonization of Streptococcus bacteria by preventing the adherence of the Streptococcus bacteria to a surface of a membrane or organ within the human, the method comprises:

a. inoculating female birds, in or about to reach their egg laying age, with a Streptococcus bacteria;

b. allowing a period of time sufficient to permit the production in the birds of antibody to the Streptococcus bacteria;

C. harvesting the eggs laid by the birds; and

d. separating the antibody-containing contents of said eggs from the shells.

2. The method of claim 1 wherein:

the Streptococcus bacteria includes S. agalactiae, S. bovis, S. mutans, S. pneumoniae, S. pyogenes, S. sanguinis, S. suis, and S. viridans.

3. The method of claim 1 including:

drying the separated antibody-containing contents of said eggs.

4. The method of claim 3 wherein:

the Streptococcus bacteria includes S. agalactiae, S. bovis, S. mutans, S. pneumoniae, S. pyogenes, S. sanguinis, S. suis, and S. viridans.

5. The method of claim 3 including:

providing a dried material, said drying of the separated antibody-containing contents of said eggs is achieved by drying the separated antibody-containing contents of said eggs.

6. The method of claim 5 wherein:

the material is a liquid product achieved by using separated antibody-containing contents of said eggs.

7. A treatment of a Streptococcus bacterial infection, the treatment comprising:

administering an antibody specific to an adheren of the Streptococcus bacteria that causes adhesion to a membrane or organ.

8. The treatment of claim 7 wherein the antibody specific to the adheren of the Streptococcus bacteria is produced by:

a. inoculating female birds, in or about to reach their egg laying age, with a Streptococcus bacteria;

b. allowing a period of time sufficient to permit the production in the birds of antibody to the Streptococcus bacteria;

C. harvesting the eggs laid by the birds; and

d. separating the antibody-containing contents of said eggs from the shells.

9. The treatment of claim 7 wherein the Streptococcus bacteria includes S. agalactiae, S. bovis, S. mutans, S. pneumoniae, S. pyogenes, S. sanguinis, S. suis, and S. viridans.

10. The treatment of claim 8 further including drying the separated antibody-containing contents of said eggs.

11. The treatment of claim 10 wherein the Streptococcus bacteria includes S. agalactiae, S. bovis, S. mutans, S. pneumoniae, S. pyogenes, S. sanguinis, S. suis, and S. viridans

12. A method for substantially reducing or eliminating the incidents of Streptococcus bacteria by inhibiting the ability of the Streptococcus bacteria to adhere to a surface of a membrane or organ thereby reducing the ability of the Streptococcus bacteria to colonize and multiply, the method comprising:

administering an antibody specific to an adheren of the Streptococcus bacteria that causes adhesion to a membrane or organ.

13. The treatment of claim 12 wherein the antibody specific to the adheren of the Streptococcus bacteria is produced by;

a. inoculating female birds, in or about to reach their egg laying age, with a Streptococcus bacteria;

b. allowing a period of time sufficient to permit the production in the birds of antibody to the Streptococcus bacteria;

c. harvesting the eggs laid by the birds; and

d. separating the antibody-containing contents of said eggs from the shells.

14. The treatment of claim 12 wherein the Streptococcus bacteria includes S. agalactiae, S. bovis, S. mutans, S. pneumoniae, S. pyogenes, S. sanguinis, S. suis, and S. viridans.

15. The treatment of claim 13 further including drying the separated antibody-containing contents of said eggs.

16. The treatment of claim 15 wherein the Streptococcus bacteria includes S. agalactiae, S. bovis, S. mutans, S. pneumoniae, S. pyogenes, S. sanguinis, S. suis, and S. viridans