IMPLANT DEVICE RELEASE AGENTS AND METHODS OF USING SAME
First Claim
Patent Images
1. A device comprising:
- a polymeric material; and
a release agent;
wherein the device is a molded, reservoir implant, and the release agent has a molecular weight (MW) of at least 1000.
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Abstract
Medical implant devices are prepared from a polymeric material and a release agent, where the device is a molded, reservoir implant, and the release agent has a molecular weight (MW) of at least 1000. The release agent may be a non-ionic surfactant such as Brij 35, polyoxyetheylene(20)sorbitan trioleate, Tween 20, Tween 80, vitamin E TPGS, and a mixture of any two or more thereof. Hydrated implants may have a surface area of about 500 mm2 or greater.
69 Citations
29 Claims
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1. A device comprising:
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a polymeric material; and a release agent; wherein the device is a molded, reservoir implant, and the release agent has a molecular weight (MW) of at least 1000. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A process comprising:
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charging a polymerization column or a mold with a monomer and a release agent; and rotating the polymerization column or mold about its longitudinal axis at a speed sufficient to displace the monomer radially outward along the interior surfaces of the polymerization column or mold; maintaining the polymerization column or mold at a position substantially parallel to the ground; polymerizing the liquid polymerizable material; and recovering a reservoir implant device; wherein the release agent has a molecular weight (MW) of at least 1000. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification