MULTISTAGE DELIVERY OF ACTIVE AGENTS
First Claim
Patent Images
1. A composition comprisingat least one first stage particle that is a micro or nanoparticle and which has (i) a body, (ii) at least one surface;
- and (iii) at least one reservoir inside the body, such that the reservoir contains at least one second stage particle that comprises at least one active agent.
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Abstract
Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
80 Citations
85 Claims
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1. A composition comprising
at least one first stage particle that is a micro or nanoparticle and which has (i) a body, (ii) at least one surface; - and (iii) at least one reservoir inside the body, such that the reservoir contains at least one second stage particle that comprises at least one active agent.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A method, comprising
administering to a subject a composition comprising: at least one first stage particle, that is a micro or nanoparticle and that has (i) a body, (ii) at least one surface;
(iii) at least one reservoir inside the body, such that the reservoir contains at least one second stage particle that comprises at least one active agent.- View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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71. A method of making a multistage delivery composition, comprising:
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(a) providing at least one first stage particle wherein the first stage particle is a micro or nanoparticle, and that has (i) a body, (ii) at least one surface and (iii) at least one reservoir inside the body; (b) providing at least one second stage particle; and (c) loading the second stage particle inside the reservoir of the first stage particle. - View Dependent Claims (72, 73, 74, 75, 80, 81, 82, 83, 84, 85)
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- 76. The method of claim 76, wherein the loading comprises loading via passive diffusion or capillary convection, or by a combination of those.
Specification