Broad Spectrum Non-Traditional Preservative System

• US 20080311231A1
• Filed: 06/10/2008
• Published: 12/18/2008
• Est. Priority Date: 12/12/2005
• Status: Abandoned Application

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta M., Caraos, Lauserpina A.
• Application Number:
  US12/136,530
• Publication Number:
  US 20080311231A1
• Time in Patent Office: Days
• US Class Current: 424/745
• CPC Class Codes: A61K 2800/524 Preservatives
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/375 the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Preservative compositions containing emollient solvents such as octanediol or Symdiol™ or octoxyglycerine monoesters in combination with organic acids such as alpha hydroxyl acids can be used for preventing microbial growth and spoilage in cosmetic and topical skin formulations with the added benefit of providing silky smooth texture to skin. The compositions may optionally contain an essential oil/component. These preservative compositions are odorless and colorless and small concentrations can be added to cosmetic/topical formulations to prevent bacterial, yeast and fungal growth within 24 to 48 hours after contamination.

Claims

1. A topical composition comprising an antimicrobial preservative composition wherein the antimicrobial preservative composition comprises a combination of emollient solvent and an alpha hydroxy acid, and wherein the combination shows greater than additive antimicrobial activity.

2. The topical composition of claim 1, further comprising an essential oil component.

3. The topical composition of claim 1, comprising a combination of emollient solvent and alpha hydroxy acid showing greater than additive antimicrobial activity in an amount effective in reducing or preventing the growth of microorganisms.

4. The topical composition of claim 1, comprising a combination of emollient solvent and alpha hydroxy acid showing greater than additive antimocrobial activity in an amount having broad spectrum antimicrobial activity.

5. The topical composition of claim 1, wherein the broad spectrum antimicrobial activity comprises activity against bacteria, yeast-like fungi or non-yeast fungi or viruses.

6. The topical composition of claim 1, wherein the emollient solvent is selected from the group consisting of octanediol, hexanediol, Symdiol™

, Sensiva™

(octoxy glycerin), propylene hepanoate, propylene caprylate and glyceryl caprylate.

7. The topical composition of claim 1, wherein the alpha hydroxy organic acid is selected from the group consisting of citric, lactic, benzoic, glycolic, mandelic, malic and tartaric acid.

8. The topical composition of claim 2, wherein the essential oil component is selected from the group consisting of thyme oil, savory oil, oregano oil, rosewood oil, lavendar oil, basil oil, farnesol, and bisbolol.

11. The topical composition of claim 1, wherein the emollient solvent is present in amounts ranging from about 0.05% to about 5% w/w.

12. The topical composition of claim 11, wherein the emollient solvent is present in amounts ranging from about 0.05% to about 1% w/w.

13. The topical composition of claim 1, wherein the AHA is present in amounts ranging from about 0.01% to about 5.0% w/w.

14. The topical composition of claim 13, wherein the AHA is present in amounts ranging from about 0.05% to about 3% w/w.

15. The topical composition of claim 2, wherein the essential oil component is present in an amount ranging from about 0.01% and 10% w/w.

16. The topical composition of claim 15, wherein the essential oil component is present in an amount ranging from about 0.05% to about 1.0% w/w.

9. A topical composition comprising an antimicrobial preservative composition wherein the antimicrobial preservative composition consists of a synergistic combination of one or more emollient solvent, an alpha hydroxy acid, an optionally an essential oil component.

10. A topical composition comprising:

from about 0.3% to about 5% of about 50% to about 99% (w/w) stock solution of an emollient solvent; and

from about 1% to about 50% alpha hydroxy acids (w/w).

17. A topical composition comprising:

about 60% octanediol, about 37% sensiva, and about 3% lactic acid.

18. A topical composition comprising:

about 80% octaneiol and about 20% lactic acid.