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Sense Antiviral Compound and Method for Treating Ssrna Viral Infection

  • US 20080311556A1
  • Filed: 08/06/2004
  • Published: 12/18/2008
  • Est. Priority Date: 08/07/2003
  • Status: Abandoned Application
First Claim
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1. An oligonucleotide analog compound for use in inhibiting replication in mammalian host cells of an RNA virus having a single-stranded, positive-sense RNA genome and selected from the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, or Coronaviridae families and hepatitis E virus, and characterized by:

  • (i) a nuclease-resistant backbone,(ii) capable of uptake by mammalian host cells,(iii) containing between 12-40 nucleotide bases,(iv) having a targeting sequence of at least 12 subunits that is complementary to a region associated with stem-loop secondary structure within the 3′

    -terminal end 40 bases of the negative-sense RNA strand of the virus, and(v) capable of forming with the negative-strand viral ssRNA genome, a heteroduplex structure having a Tm of dissociation of at least 45°

    C. and disruption of said stem-loop secondary structure.

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