Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy
First Claim
1. A method for monitoring the status of a disease associated with the soluble VEGF-R2 pathway in a patient, and/or monitoring how a patient with said disease is responding to a therapy comprising immunologically detecting and quantifying serial changes in soluble VEGF-R2 protein levels in patient samples taken over time, wherein increasing levels of soluble VEGF-R2 protein over time indicate disease progression or a negative response to said therapy, and wherein decreasing levels of soluble VEGF-R2 protein over time indicate disease remission or a positive response to said therapy.
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Abstract
The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of soluble VEGF-R2 as a biomarker for multi-kinase inhibitors.
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Citations
28 Claims
- 1. A method for monitoring the status of a disease associated with the soluble VEGF-R2 pathway in a patient, and/or monitoring how a patient with said disease is responding to a therapy comprising immunologically detecting and quantifying serial changes in soluble VEGF-R2 protein levels in patient samples taken over time, wherein increasing levels of soluble VEGF-R2 protein over time indicate disease progression or a negative response to said therapy, and wherein decreasing levels of soluble VEGF-R2 protein over time indicate disease remission or a positive response to said therapy.
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17. A method of therapy selection for a human patient with a disease, comprising:
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(a) immunologically detecting and quantifying the average level of soluble VEGF-R2 protein in control samples taken from individuals of a control population; (b) immunologically detecting and quantifying serial changes in soluble VEGF-R2 protein levels in equivalent patient samples taken from the patient over time; (c) comparing the levels of soluble VEGF-R2 protein in the patient'"'"'s samples to the average level of soluble VEGF-R2 protein in the control samples; and (d) determining whether to use conventional therapy and/or VEGF pathway-directed therapy to treat the patient based upon the differences between the levels of soluble VEGF-R2 protein in the patient'"'"'s samples and the average level of soluble VEGF-R2 protein in the control samples, and in view of the serial changes among the levels of soluble VEGF-R2 protein in the patient'"'"'s samples. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A diagnostic method to detect a disease associated with a VEGF pathway in a patient comprising:
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(a) immunologically detecting and quantifying the average level of soluble VEGF-R2 protein in control samples taken from individuals of a control population; (b) immunologically detecting and quantifying serial changes in soluble VEGF-R2 protein in samples of a patient sample taken from a patient over time; and (c) comparing the levels of soluble VEGF-R2 protein in the patient'"'"'s samples to the average level of soluble VEGF-R2 protein in the control samples; wherein a level of soluble VEGF-R2 protein in the patient'"'"'s samples that is above the average level of soluble VEGF-R2 protein in the control samples is indicative of an activated VEGF pathway and the presence of disease in the patient. - View Dependent Claims (28)
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Specification