SAMPLE ANALYZER AND SAMPLE ANALYZING METHOD

• US 20080311678A1
• Filed: 06/12/2008
• Published: 12/18/2008
• Est. Priority Date: 06/15/2007
• Status: Abandoned Application

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: MOTOTSU, Kazunori, MATSUI, Jun, OOTANI, Toshihiro, MATSUE, Miyuki, KATSUMI, Hironori
• Application Number:
  US12/138,136
• Publication Number:
  US 20080311678A1
• Time in Patent Office: Days
• US Class Current: 436/526
• CPC Class Codes: G01N 35/0098 involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation magnetic particles used in immunoassays G01N33/54326; magnetic separation in general B03C
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence

Abstract

The present invention is to present a sample analyzer which is capable of separate and dispose of the reaction container and the reaction liquid respectively even when magnetic particles are included in a reagent. The sample analyzer 1 comprises: a detector 16 for detecting the target substance by using a cuvette 300 which contains the target substance captured by the magnetic particle; an adsorption section 183 for magnetically adsorbing the magnetic particle in the cuvette 300; a liquid aspiration section 18 for aspirating a liquid in the cuvette 300 in a state in which the magnetic particle in the cuvette 300 is magnetically adsorbed by the adsorption section 183; and a disposal section 19 for accommodating the cuvette 300.

Claims

1. A sample analyzer for analyzing a target substance contained in a sample by using a reagent containing a magnetic particle, comprising:

a detector for detecting the target substance by using a container which contains the target substance captured by the magnetic particle;

an adsorption section for magnetically adsorbing the magnetic particle in the container, the target substance in the container having been detected by the detector;

a liquid aspiration section for aspirating a liquid in the container in a state in which the magnetic particle in the container is magnetically adsorbed by the adsorption section, the target substance in the container having been detected by the detector; and

a disposal section for accommodating the container, the liquid in the container having been aspirated by the liquid aspiration section.

2. The sample analyzer of claim 1, wherein

the adsorption section comprises:

a concavity for housing the container; and

a magnet for magnetically adsorbing the magnetic particle in the container housed in the concavity.

3. The sample analyzer of claim 2, wherein

the magnet of the adsorption section is arranged laterally to the container housed in the concavity.

4. The sample analyzer of claim 1, further comprising

a transfer section for transferring the container to the disposal section, the liquid in the container having been aspirated by the liquid aspiration section.

5. The sample analyzer of claim 4, wherein

the transfer section comprises:

a gripper for gripping the container; and

a moving device for moving the gripper gripping the container to the disposal section.

6. The sample analyzer of claim 5, wherein

the transfer section is configured to transfer the container, in which the magnetic particle remains, to the disposal section.

7. The sample analyzer of claim 1, wherein

the liquid adsorption section comprises a tapered nozzle for aspirating the liquid in the container.

8. The sample analyzer of claim 7, wherein

a bottom end of the nozzle is formed so as to be inclined relative to an axial direction of the nozzle.

9. The sample analyzer of claim 7, further comprising

a washing unit for washing the nozzle.

10. The sample analyzer of claim 9, wherein

the washing unit is arranged on a line extending in a direction in which the nozzle is moved to aspirate the liquid in the container.

11. The sample analyzer of claim 1, wherein

the disposal section comprises:

a disposal hole; and

a used container accommodating section which is arranged below the disposal hole and which is capable of being withdrawn from the sample analyzer.

12. The sample analyzer of claim 11, wherein

the used container accommodating section comprises a disposable receptacle for accommodating used containers.

13. A sample analyzer for analyzing a target substance contained in a sample by using a reagent containing a magnetic particle, comprising:

a detector for detecting the target substance by using a container which contains the target substance captured by the magnetic particle;

an adsorption section for magnetically adsorbing the magnetic particle in the container;

a liquid aspiration section for aspirating a liquid in the container;

a disposal section for accommodating a used container; and

a controller for controlling the detector, the adsorption section and the liquid aspiration section so as to magnetically adsorb the magnetic particle in the container after detecting the target substance in the container, and to aspirate the liquid in the container while magnetically adsorbing the magnetic particle in the container.

14. The sample analyzer of claim 13, wherein

the adsorption section comprises:

a concavity for housing the container; and

a magnet for magnetically adsorbing the magnetic particle in the container housed in the concavity.

15. The sample analyzer of claim 13, further comprising

a transfer section for transferring the container to the disposal section,

wherein

the controller controls the transfer section and the liquid aspiration section so as to transfer the container to the disposal section after aspirating the liquid from the container.

16. The sample analyzer of claim 13, wherein

the liquid adsorption section comprises a tapered nozzle for aspirating the liquid in the container;

a bottom end of the nozzle is formed so as to be inclined relative to an axial direction of the nozzle; and

the controller controls the liquid aspiration section so as to aspirate the liquid while contacting the bottom end of the nozzle with a bottom of the container.

17. The sample analyzer of claim 16, further comprising

a washing unit for washing the nozzle,

wherein

the controller controls the washing unit and the liquid aspiration section so as to wash the nozzle after aspirating the liquid from the container.

18. A sample analyzing method for analyzing a target substance contained in a sample by using a reagent containing a magnetic particle, comprising steps of:

(a) detecting the target substance by using a container which contains the target substance captured by the magnetic particle;

(b) magnetically adsorbing the magnetic particle in the container after performing the step (a);

(c) aspirating a liquid in the container while magnetically adsorbing the magnetic particle in the container;

(d) disposing of the container after performing the step (c).

19. The sample analyzing method of claim 18, further comprising a step of

(e) washing a nozzle after aspirating the liquid in the container by the nozzle.

20. The sample analyzing method of claim 19, wherein

a bottom end of the nozzle is formed so as to be inclined relative to an axial direction of the nozzle;

and

the step (c) comprises a step of aspirating the liquid while contacting the bottom end of the nozzle with a bottom of the container.