KMUP-1 CAPABLE OF TREATING HYPERTENSION

• US 20080312249A1
• Filed: 09/19/2007
• Published: 12/18/2008
• Est. Priority Date: 06/15/2007
• Status: Abandoned Application

• Current Assignee: Kaohsiung Medical University
• Original Assignee: Kaohsiung Medical University
• Inventors: CHEN, Ing-Jun
• Application Number:
  US11/857,483
• Publication Number:
  US 20080312249A1
• Time in Patent Office: Days
• US Class Current: 514/252.16
• CPC Class Codes: A61K 31/497 containing further heterocyclic rings
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/12 Antihypertensives

Abstract

A pharmaceutical composition for treating the hypertension is provided. The pharmaceutical composition comprises a chemical compound of 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine and one of a pharmaceutical acceptable salt thereof and a solvate thereof, wherein the chemical compound treats the hypertension by cGMP-dependent inhibition on Rho kinase.

Claims

1. A method for treating a hypertension, comprising a step of administering to a mammal a therapeutically effective amount of a compound of 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine.

2. A method as claimed in claim 1, wherein the administration is one selected from a group consisting of an oral injection, an intraperitoneal injection and an intravenous injection.

3. A method as claimed in claim 1, wherein the hypertension is a pulmonary hypertension.

4. A method as claimed in claim 1, wherein the hypertension is a spontaneous hypertension.

5. A method as claimed in claim 1, wherein the compound causes a cGMP-dependent inhibition on Rho kinase.

6. A method as claimed in claim 1, further comprising a step of administering the compound with the pharmaceutically effective carrier thereof.

7. A method for treating a hypertension, comprising a step of administering to a mammal a therapeutically effective amount of compounds of 7-[2- [4-(2-fluorobenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine and 7-[2-[4-(2-trifluoromethylbenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine.