Biosensor and its production

• US 20080314745A1
• Filed: 01/25/2008
• Published: 12/25/2008
• Est. Priority Date: 04/17/2007
• Status: Abandoned Application

• Current Assignee: Tesa SE (Maxingvest AG)
• Original Assignee: Tesa AG (Maxingvest AG)
• Inventors: Neubert, Ingo, Klose, Maren
• Application Number:
  US12/020,008
• Publication Number:
  US 20080314745A1
• Time in Patent Office: Days
• US Class Current: 204/403.01
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: Y10T 428/254 Polymeric or resinous material

Abstract

Biosensor for analyzing biological fluids having:

• • a functional base layer A1 provided with electrical interconnects and at least partially with an analytical detection reagent,
  • a functional layer A3 and
  • a double-sided pressure-sensitive adhesive tape A2 which joins the functional layers A1 and A3 and forms a measuring channel whose lid is formed by functional layer A3 and whose base is formed by functional layer A1,
    the functional layer A3 having at least one hydrophilic and at least one hydrophobic region, the hydrophobic and hydrophilic regions being disposed such that they at least partially form an inside of the wall of the measuring channel formed by functional layer A2, and one hydrophilic region of the functional layer A3 ends flush with a front edge of the measuring channel, from which the biological fluid is supplied.

Claims

1. Biosensor for analyzing biological fluids, said biosensor comprising at least the following layers:

a functional layer A1 which constitutes a base layer of the biosensor and is provided with electrical interconnects and at least partially with an analytical detection reagent,

a functional layer A3 and

a double-sided pressure-sensitive adhesive tape A2 which joins the functional layers A1 and A3 to one another and in which a measuring channel is provided having a lid formed by the functional layer A3 and a base formed by the functional layer A1,

the functional layer A3 having at least one hydrophilic and at least one hydrophobic region, the hydrophobic and hydrophilic regions of the functional layer A3 being disposed such that they at least partially form an inside of the wall of the measuring channel formed by the functional layer A2, and

one hydrophilic region of the functional layer A3 ends at a front edge of the measuring channel, from which the biological fluid is supplied to the medical biosensor.

2. Biosensor according to claim 1,

wherein

on the functional layer A3 there are two or more hydrophilic and two or more hydrophobic regions which are disposed adjacent one another and which contact one another.

3. Biosensor according to claim 1,

wherein

the hydrophobic and optionally also the hydrophilic region on the functional layer A3 form a partial but uniform coherent area.

4. Biosensor according to claim 1,

wherein

on the functional layer A3 the hydrophobic region extends partially over the hydrophilic region, which optionally is coated over the whole area of the functional layer A3.

5. Biosensor according to claim 1,

wherein

the hydrophilic region on the functional layer A3 has a layer thickness that is not more than 3 μ

m and/or the hydrophobic region on the functional layer A3 has a layer thickness that is 0.1 μ

m to 3 μ

m.

6. Biosensor according to claim 1,

wherein

the hydrophilic and the hydrophobic regions on the functional layer A3 comprise print.

7. Biosensor according to claim 1,

wherein

the hydrophilic region on the functional layer A3 is in the form of lines having a line width of 0.3 to 10 mm and/or the hydrophobic region on the functional layer A3 is in the form of lines having a line width of 0.5 to 10 mm.

8. Biosensor according to claim 1,

wherein

the hydrophilic region or regions of the functional layer A3 have the following properties:

a surface tension of at least 60 mN/m and

a contact angle with water of less than 30°

.

9. Biosensor according to claim 1,

wherein

the hydrophilic region of the functional layer A3 comprises a coat of varnish which is composed of polyvinyl alcohol as binder, a surfactant and water.

10. Biosensor according to claim 1,

wherein

the hydrophilic region of the functional layer A3 comprises at least one anionic surfactant.

11. Biosensor according to claim 1,

wherein

the hydrophobic region or regions of the functional layer A3 have the following properties:

a surface tension of not more than 30 mN/m,

a contact angle with water of greater than 95° and

a release value with an acrylate test adhesive tape of less than 50 cN/cm.

12. Biosensor according to claim 1,

wherein

the hydrophobic regions of the functional layer A3 is composed of a release varnish based on a fluoropolymer or a silicone polymer, each of which is optionally UV-crosslinkable.

13. Biosensor according to claim 1,

wherein

the measuring channel formed by the functional layers A1 and A3 and also by two parallel walls formed by the pressure-sensitive adhesive tape A2 is open at both ends.

14. Biosensor according to claim 1,

wherein

the pressure-sensitive adhesive tape of the functional layer A2 is composed of a pressure-sensitive adhesive whose shear deformation after 15 min at 40°

C. under a load of 500 g is less than 130 μ

m.

15. A method comprising using a biosensor according to claim 1 in medical sensors or diagnostic strips for analyzing biological fluids.

16. A medical sensor comprising a biosensor according to claim 1.

17. A diagnostic strip comprising a biosensor according to claim 1.