GLYCEROL AS A PREDICTOR OF GLUCOSE TOLERANCE

• US 20080319176A1
• Filed: 02/25/2008
• Published: 12/25/2008
• Est. Priority Date: 10/22/1999
• Status: Abandoned Application

• Current Assignee: Complexe Hospitalier De La Sagamie, Whitehead Institute for Biomedical Research
• Original Assignee: Complexe Hospitalier De La Sagamie
• Inventors: Daly, Mark, Hudson, Thomas J., Arsenault, Steve, Rioux, John D., Gaudet, Daniel
• Application Number:
  US12/036,960
• Publication Number:
  US 20080319176A1
• Time in Patent Office: Days
• US Class Current: 536/23.2
• CPC Class Codes: C12N 9/1205 Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
• CPC Class Codes: C12Q 1/48 involving transferase
• CPC Class Codes: C12Q 1/485 involving kinase
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers
• CPC Class Codes: C12Y 207/0103 Glycerol kinase (2.7.1.30)
• CPC Class Codes: G01N 2333/91215 with a definite EC number (2.7.1.-)
• CPC Class Codes: G01N 2500/00 Screening for compounds of potential therapeutic value
• CPC Class Codes: G01N 2800/042 Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
• CPC Class Codes: G01N 2800/52 Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/6893 related to diseases not provided for elsewhere

Abstract

Novel alterations in the glycerol kinase gene are described. Also described are methods of predicting or assisting in the prediction of impaired glucose tolerance and type 2 diabetes mellitus.

Claims

1. An isolated nucleic acid molecule comprising a portion of SEQ ID NO:

3, wherein said portion is at least 10 nucleotides in length and includes nucleotide position 29 of exon 10 of a glycerol kinase (GK) gene, and wherein said nucleic acid molecule comprises a mutant allele of said GK gene at said nucleotide position 29.