Apparatus and Method for Measuring Constituent Concentrations within a Biological Tissue Structure

• US 20080319285A1
• Filed: 07/06/2006
• Published: 12/25/2008
• Est. Priority Date: 07/06/2005
• Status: Active Grant

• Current Assignee: Afon Technology Ltd.
• Original Assignee: Ferlin Medical Limited
• Inventors: Hancock, Christopher Paul
• Granted Patent: US 8,882,670 B2
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes

Abstract

Apparatus for minimally invasively measuring concentrations of constituents contained within a biological tissue structure includes a microwave energy source arranged generate a range of microwave frequencies, a first antenna coupled to the microwave energy source and arranged to transmit at least a portion of the microwave energy into the tissue structure, a second antenna arranged to receive at least a portion of the microwave energy transmitted through the tissue structure, a signal processor arranged to determine the resonant frequency of the received microwave energy, and a data processor arranged to provide an output of the concentration of constituents within the biological tissue structure according to the determined resonant frequency.

Claims

1. Apparatus for minimally invasively measuring concentrations of constituents contained within a biological tissue structure, the apparatus comprising:

a microwave energy source arranged to generate a range of microwave frequencies;

a first antenna coupled to the microwave energy source and arranged to transmit at least a portion of the microwave energy into the tissue structure;

a second antenna arranged to receive at least a portion of the microwave energy transmitted through the tissue structure;

a signal processor arranged to determine the resonant frequency of the received microwave energy; and

a data processor arranged to provide an output of the concentration of constituents within the biological tissue structure according to the determined resonant frequency.

2. Apparatus according to claim 1, wherein the signal processor is arranged to measure the magnitude response of the ratio of the received microwave energy to the transmitted microwave energy and determine the frequency at which a minima or maxima in the magnitude response occurs, said frequency being the resonant frequency.

3. Apparatus according to claim 2, wherein the signal processor is arranged to determine the 3 dB bandwidth of the magnitude response for the frequency of the minima or maxima and thereby derive the Q factor of the biological tissue structure.

4. Apparatus according to claim 3, wherein the data processor is arranged to correlate the derived value of Q factor to a constituent concentration value.

5. Apparatus according to claim 1, wherein the signal processor is arranged to measure the phase response of the ratio of the received microwave energy to the transmitted microwave energy and determine the frequency at which a minima or maxima in the phase response occurs, said frequency being the resonant frequency.

6. Apparatus according to claim 1, wherein the first and second antennas comprise a single transceiver wherein the received microwave energy comprises reflected microwave energy.

7. Apparatus according to claim 6, wherein the apparatus further comprises a reflector plate arranged to reflect microwave energy transmitted from the single antenna back to said antenna.

8. Apparatus according to claim 1, wherein the microwave energy source is arranged to generate microwave energy over a range of frequencies such that at the resonant frequency the biological tissue structure forms a single wave resonance cavity.

9. Apparatus according to claim 1, wherein the microwave energy source is arranged to generate microwave energy over a range of frequencies such that at the resonant frequency the biological tissue structure forms a half wave resonance cavity.

10. Apparatus according to claim 1, wherein the microwave energy source is arranged to generate microwave energy within the frequency range of 8 GHz to 18 GHz.

11. Apparatus according to claim 10, wherein the microwave source is arranged to generate microwave energy within a number of frequency bandwidths within said frequency range.

12. Apparatus according to claim 1, wherein the first and second antennas comprise patch antennas, each antenna having a radiating patch and a microwave feed line.

13. Apparatus according to claim 12, wherein the microwave feed line comprises a micro-strip connected to the radiating patch.

14. Apparatus according to claim 12, wherein the microwave feed line comprises a coaxial feed.

15. Apparatus according to claim 12, wherein the microwave feed line is electromagnetically coupled to the radiating patch.

16. Apparatus according to claim 12, wherein the radiating patch includes an annular slot formed therein.

17. Apparatus according to claim 1, wherein the first and second antennas comprise spiral antennas.

18. Apparatus according to claim 1, wherein the first and second antennas comprise waveguide antennas.

19. Apparatus according to claim 1, wherein the first and second antennas are arranged to be non-invasively attached to the biological tissue structure.

20. Apparatus according to claim 1, wherein the first and second antennas comprise one of waveguide antennas or coaxial monopole antennas, each antenna having an inner and an outer conductor.

21. Apparatus according to claim 20, wherein the inner antenna comprises a needle like structure arranged to pierce the surface layer of the biological tissue.

22. Apparatus according to claim 21, wherein the inner antenna is hollow and is arranged to be in fluid communication with a fluid source.

23. Apparatus according to claim 21, wherein the outer antenna is arranged to pierce the surface layer of the biological tissue.

24. Apparatus according to claim 1, wherein the data processor is arranged to correlate the determined resonant frequency to the thickness of the biological tissue structure to provide the constituent concentration information.

25. Apparatus according to claim 24, wherein a value for the biological tissue structure thickness is provided as a predetermined input parameter.

26. Apparatus according to claim 24, wherein the signal processor is arranged to measure the capacitance of the biological tissue structure between the first and second antennas, from which the thickness value is derived.

27. Apparatus according to claim 1, wherein said first and second antennas are arranged to be attached to either side of at least one of an earlobe or the skin interconnecting a thumb and forefinger.

28. Apparatus according to claim 1, wherein at least the microwave source, and first and second antennas are arranged as a portable assembly for wearing by an individual.

29. Apparatus according to claim 1, wherein at least one of the signal processor and data processor comprise one from the list of a personal computer, a laptop computer, a mobile computer and a mobile telephone.

30. Apparatus according to claim 1, wherein the constituent concentration comprises at least blood-glucose, blood-alcohol or cholesterol.

31. A method of minimally invasively measuring concentrations of constituents contained within a biological tissue structure, the method comprising:

generating a range of microwave frequencies;

transmitting at least a portion of the generated microwave energy into the tissue structure;

receiving at least a portion of the microwave energy transmitted through the tissue structure;

determining the resonant frequency of the received microwave energy; and

providing an output of the concentration of constituents within the biological tissue structure according to the determined resonant frequency.

32. The method of claim 31, wherein the magnitude response of the ratio of the received microwave energy to the transmitted microwave energy is measured and the frequency at which a minima or maxima in the magnitude response occurs determined, said frequency being the resonant frequency.

33. The method of claim 32, wherein the 3 dB bandwidth of the magnitude response for the frequency of the minima or maxima is determined and therefore the Q factor of the biological tissue structure is derived.

34. The method of claim 33, wherein the derived value of Q factor is correlated to a constituent concentration value.

35. The method of claim 31, wherein the phase response of the ratio of the received microwave energy to the transmitted microwave energy is measured and the frequency at which a minima or maxima in the phase response occurs is determined, said frequency being the resonant frequency.

36. The method of claim 31, wherein the microwave energy generated over a range of frequencies such that at the resonant frequency the biological tissue structure forms a single wave resonance cavity.

37. The method of claim 31, wherein the microwave energy generated over a range of frequencies such that at the resonant frequency the biological tissue structure forms a half wave resonance cavity.

38. The method of claim 31, wherein the microwave energy is generated within the frequency range of 8 GHz to 18 GHz.

39. The method of claim 31, wherein the microwave energy is generated within a number of frequency bandwidths within said frequency range.

40. The method of claim 31, wherein the determined resonant frequency is correlated to the thickness of the biological tissue structure to provide the constituent concentration information.

41. The method of claim 40, wherein a value for the biological tissue structure thickness is provided as a predetermined input parameter.

42. The method of claim 40, wherein the capacitance of the biological tissue structure is measured, from which the thickness value is derived.

43. The method of claim 31, the biological tissue structure comprises one of an earlobe or the skin interconnecting a thumb and forefinger.

44. The method of claim 31, wherein the constituent concentration comprises at least blood-glucose, blood-alcohol or cholesterol.