DRUG-ELUTING GRAFT
First Claim
1. A device for the local delivery of a substance into a natural tissue conduit in a mammalian body, comprising:
- a first biocompatible element that is configured to be affixed to the conduit and having a first surface, an opposite second surface, and an intermediate macroporous portion that communicates the second surface with the first surface;
a second microporous element that overlays the second surface of the first element; and
a third element comprised of a substantially non-porous biocompatible material that overlays the second element, a reservoir having an interior being formed between the second element and the third element, the interior of the reservoir being capable of fluid communication with the conduit via the second microporous element and the macroporous portion of the first element such that, when in use, a substance in the reservoir may be delivered into the conduit.
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Accused Products
Abstract
Embodiments of the present invention provide a device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first element capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. In embodiments, the first element may be fully or partially microporous or a separate intermediate microporous membrane may be provided. Also provided are methods of mixing or moving a drug within a reservoir using various mixing elements. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing a device in accordance with embodiments of the present invention.
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Citations
25 Claims
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1. A device for the local delivery of a substance into a natural tissue conduit in a mammalian body, comprising:
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a first biocompatible element that is configured to be affixed to the conduit and having a first surface, an opposite second surface, and an intermediate macroporous portion that communicates the second surface with the first surface; a second microporous element that overlays the second surface of the first element; and a third element comprised of a substantially non-porous biocompatible material that overlays the second element, a reservoir having an interior being formed between the second element and the third element, the interior of the reservoir being capable of fluid communication with the conduit via the second microporous element and the macroporous portion of the first element such that, when in use, a substance in the reservoir may be delivered into the conduit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A device for the local delivery of a substance into a natural tissue conduit in a body, comprising:
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a first element comprised of a biocompatible material that is configured to be affixed to the conduit and has a first surface, an opposite second surface, and an intermediate portion having at least a portion thereof that is microporous that communicates the second surface with the first surface, wherein the first surface of the intermediate portion is configured to contact the lumen of the conduit; and a second element comprised of a substantially non-porous biocompatible material that overlays the second surface of the first element, a reservoir having an interior being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit via the microporous portion such that, when in use, a substance in the reservoir is delivered into the conduit. - View Dependent Claims (18, 19)
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20. A device for the local delivery of a substance into a natural tissue conduit in a mammalian body, comprising:
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a first element comprised of a biocompatible material that is configured to be affixed to the conduit and has a first surface, an opposite second surface, and an intermediate porous portion that communicates the second surface with the first surface; a second element comprised of a substantially non-porous biocompatible material that overlays the first element, a reservoir having an interior being formed between the first element and the second element, the interior of the reservoir having one or more mixing elements and being capable of fluid communication with the conduit via the porous portion of the first element such that, when in use, a substance in the reservoir is delivered into the conduit. - View Dependent Claims (21, 22)
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23. A method of locally delivering a substance into a natural tissue conduit in a mammalian body, comprising:
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forming a device comprising a first element comprised of a biocompatible material that is configured to be affixed to the conduit having a first surface, an opposite second surface, and an intermediate macroporous portion that communicates the second surface with the first surface, wherein the first surface of the macroporous portion is configured to contact the lumen of the conduit, and a second microporous element that overlays the second surface of the first element; and
a third element comprised of a substantially non-porous biocompatible material that overlays the second element, a reservoir having an interior being formed between the third element and the second element, the interior of the reservoir being capable of fluid communication with the conduit via the macroporous portion and the microporous element such that, when in use, a substance placed in the reservoir is delivered into the conduit;affixing the device to the natural tissue conduit such that the first surface of the macroporous portion contacts the lumen of the conduit and such that the interior of the reservoir is in fluid communication with the conduit via the microporous second element and the macroporous portion of the first element; and placing a substance in the reservoir. - View Dependent Claims (24, 25)
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Specification