Small Volume in Vitro Analyte Sensor
3 Assignments
0 Petitions
Accused Products
Abstract
A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.
The amount of analyte can be determined by coulometry, amperometry, voltammetry, and potentiometry. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.
-
Citations
152 Claims
-
1-132. -132. (canceled)
-
133. An optical sensor for determining the concentration of an analyte, comprising:
-
at least two support films, wherein at least one of said support films form at least one boundary area wherein a biological fluid is analyzed, wherein said support films are tapered; at least one sorbent material associated with said boundary area; and a reagent layer having an enzyme-based composition including glucose oxidase. - View Dependent Claims (134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150)
-
-
151. A method for using an optical sensor for determining the concentration of an analyte, comprising:
-
providing at least two support films, wherein at least one of said support films form at least one boundary area wherein a biological fluid is analyzed, wherein said support films are tapered; providing at least one sorbent material associated with said boundary area; and providing a reagent layer having an enzyme-based composition including glucose oxidase and a dye mediator.
-
-
152. An optical sensor for determining the concentration of an analyte, comprising:
-
at least two support films, wherein at least one of said support films form at least one boundary area wherein a biological fluid is analyzed, wherein at least a portion of at least one of said support films is transparent or translucent, wherein said support films are tapered; at least one sorbent material associated with said boundary area; and a reagent layer having an enzyme-based composition including glucose oxidase and a dye mediator.
-
Specification