ORTHOVOLTAGE RADIOSURGERY
First Claim
1. A method, of treating tissue at a target zone deep to a surface of a patient'"'"'s body by emitting, from an x-ray source having a system axis defined in a global coordinate system, a collimated x-ray beam having a beam axis defined in the global coordinate system, said method comprising:
- (a) determining a reference axis defined relative to the patient'"'"'s body, the reference axis having a known position and orientation in the global coordinate system;
(b) determining a treatment axis that intersects the target zone, the treatment axis having a known position and orientation with respect to the reference axis and with respect to the system axis in the global coordinate system;
(c) positioning the x-ray source to a first position with respect to the system axis, such that the beam axis intersects the treatment axis at (i) a first treatment site within the target zone and (ii) a first incident angle with respect to the treatment axis, and such that the beam axis intersects the surface of the patient'"'"'s body at a first location;
(d) emitting an x-ray beam toward the target zone along the beam axis, to irradiate the target zone with a first radiation dose;
(e) rotating the x-ray source about the system axis to a second position with respect to the system axis, such that the beam axis intersects the treatment axis at (i) a second treatment site within the target zone and (ii) at a second incident angle with respect to the treatment axis, and such that the beam axis intersects the surface of the patient'"'"'s body at a second location that is separated from the first location by a first distance; and
(f) emitting an x-ray beam toward the target zone along the beam axis, to irradiate the target zone with a second radiation dose.
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Accused Products
Abstract
A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
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Citations
47 Claims
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1. A method, of treating tissue at a target zone deep to a surface of a patient'"'"'s body by emitting, from an x-ray source having a system axis defined in a global coordinate system, a collimated x-ray beam having a beam axis defined in the global coordinate system, said method comprising:
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(a) determining a reference axis defined relative to the patient'"'"'s body, the reference axis having a known position and orientation in the global coordinate system; (b) determining a treatment axis that intersects the target zone, the treatment axis having a known position and orientation with respect to the reference axis and with respect to the system axis in the global coordinate system; (c) positioning the x-ray source to a first position with respect to the system axis, such that the beam axis intersects the treatment axis at (i) a first treatment site within the target zone and (ii) a first incident angle with respect to the treatment axis, and such that the beam axis intersects the surface of the patient'"'"'s body at a first location; (d) emitting an x-ray beam toward the target zone along the beam axis, to irradiate the target zone with a first radiation dose; (e) rotating the x-ray source about the system axis to a second position with respect to the system axis, such that the beam axis intersects the treatment axis at (i) a second treatment site within the target zone and (ii) at a second incident angle with respect to the treatment axis, and such that the beam axis intersects the surface of the patient'"'"'s body at a second location that is separated from the first location by a first distance; and (f) emitting an x-ray beam toward the target zone along the beam axis, to irradiate the target zone with a second radiation dose. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. An x-ray treatment system, for treating tissue at a target zone, deep to a surface of a patient'"'"'s body, by emission of a collimated x-ray beam, the system comprising:
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(a) an alignment assembly operative to determine a reference axis defined relative to the patient'"'"'s body, which axis has a position and orientation in a global coordinate system, (b) an x-ray source positionable in relation to a system axis defined in the global coordinate system, and operative to emit a collimated x-ray beam having a beam axis defining a beam path; (c) a beam-positioning assembly operative to move the beam source to place the beam axis at selected positions with respect to the system axis, and (d) a control unit operatively connected to the alignment assembly, x-ray source, and beam-positioning assembly, the control unit operating to; (d1) determine, from information received from the alignment assembly related to an anatomical representation of the body, a treatment axis having a position and orientation with respect to the reference axis in the global coordinate systems; (d2) direct the beam-positioning assembly to move the x-ray source to a first position with respect to the system axis, at which the beam axis intersects the treatment axis at the target zone at an incident angle with respect to the treatment axis, such that the beam axis intersects a surface of the body at a first position; (d3) direct the x-ray source to emit the x-ray beam toward the target zone along the beam axis, to irradiate the target zone with a radiation dose; (d4) direct the beam-positioning assembly to move the x-ray source with respect to the system axis to a second position, at which the beam axis intersects the treatment axis at the target zone at an incident angle with respect to the treatment axis, so that the beam axis intersects the surface of the body at a second position, different from the first position; and (d5) direct the x-ray source to emit the x-ray beam toward the target zone along the beam axis, to irradiate the target zone with a radiation dose. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method, of determining a trajectory of a radiotherapy beam, comprising:
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identifying an anterior-posterior axis of an eye; orienting a first treatment axis to be substantially parallel to the anterior-posterior axis; determining a first x-ray beam trajectory that intersects the first treatment axis at an incident angle; and emitting a first x-ray beam along the first x-ray beam trajectory such that the first x-ray beam trajectory intersects the sclera of the eye at a first point located a selected distance from a border of a structure of the eye. - View Dependent Claims (43, 44, 45, 46, 47)
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Specification