Method of Making Optical Probes for Non-Invasive Analyte Measurements
First Claim
1. A method for fabricating an optical probe, comprising:
- fabricating a plurality of ribbons of optical fibers wherein each ribbon comprises a plurality of optical fibers and wherein the optical fibers comprise illumination or collection fibers,verifying at least one parameter of each ribbon to determine the suitability of each ribbon for inclusion in the optical probe,stacking the verified suitable ribbons to form a sample interface comprising linear rows of the stacked ribbons,verifying at least one parameter of the stacked ribbons to determine the suitability of the sample interface,polishing the surface of the sample interface, andverifying at least one parameter of the sample interface to determine the suitability of the polished sample interface.
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Accused Products
Abstract
An optical probe for non-invasively measuring an analyte property in a biological sample of a subject, comprises a plurality of illumination fibers that deliver source light from an optical probe input to a sample interface, a plurality of collection fibers that deliver light returned from the sample interface to an optical probe output, and wherein the illumination and collection fibers are oriented substantially perpendicular to the sample interface and the illumination and collection fibers are stacked in a plurality of linear rows to provide a stack of fibers arranged in a rectangular pattern. The optical probe is amenable to manufacturing on a scale consistent with a commercial product. Methods of making such probes are described.
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Citations
20 Claims
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1. A method for fabricating an optical probe, comprising:
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fabricating a plurality of ribbons of optical fibers wherein each ribbon comprises a plurality of optical fibers and wherein the optical fibers comprise illumination or collection fibers, verifying at least one parameter of each ribbon to determine the suitability of each ribbon for inclusion in the optical probe, stacking the verified suitable ribbons to form a sample interface comprising linear rows of the stacked ribbons, verifying at least one parameter of the stacked ribbons to determine the suitability of the sample interface, polishing the surface of the sample interface, and verifying at least one parameter of the sample interface to determine the suitability of the polished sample interface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification