Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors
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Abstract
Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
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Citations
19 Claims
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1-10. -10. (canceled)
- 11. A method of measuring a compound or metabolite thereof, comprising contacting a reporter compound of the following formula:
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12. A method of measuring a compound or metabolite thereof, comprising contacting a reporter compound of the following formula:
- 18. A chromophore of the following formula:
Specification