MULTI-WELL RESERVOIR PLATE AND METHODS OF USING SAME
First Claim
1. A carrier comprising:
- a frame; and
a plate coupled to the frame, the plate having a plurality of receptacles formed in the plate, at least one receptacle having an upper portion having a first wall forming a first volume, a tapered portion having a tapered wall forming a second volume, and a lower portion having a lower wall forming a passage, the tapered portion is disposed between the upper portion and the lower portion, the upper portion includes a receiving opening with a first perimeter, the lower portion includes a discharge opening at one end of the passage, wherein the passage is in fluid communication with the first volume of the upper portion, the discharge opening includes a with a second perimeter that is smaller than the receiving opening of the upper portion by an extent that a substance that is received in one or both of the first and second volumes remains therein until acted upon by an amount of applied force.
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Accused Products
Abstract
The present disclosure generally relates to a multi-well reservoir plate and methods of using the same. The multi-well reservoir plate includes a frame portion coupled to a plate portion, where a number of receptacles are formed in the plate portion. The receptacles or wells are sized to receive and support a substance without permitting the substance to leak or discharge from a passage formed in a lower portion of the well and in fluid communication with an upper portion of the well where the substances is supported. In one embodiment, the wells are at least partially filled with a substance, the substance is supported the in the wells for an amount of time, and then the substance is discharged from the wells by applying a force to the substance. By way of example, the force may be a pressure applied to an upper surface of the substance, a pressure (e.g., vacuum) applied to a lower surface of the substance, and/or an inertial force generated by an acceleration of the substance.
73 Citations
23 Claims
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1. A carrier comprising:
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a frame; and a plate coupled to the frame, the plate having a plurality of receptacles formed in the plate, at least one receptacle having an upper portion having a first wall forming a first volume, a tapered portion having a tapered wall forming a second volume, and a lower portion having a lower wall forming a passage, the tapered portion is disposed between the upper portion and the lower portion, the upper portion includes a receiving opening with a first perimeter, the lower portion includes a discharge opening at one end of the passage, wherein the passage is in fluid communication with the first volume of the upper portion, the discharge opening includes a with a second perimeter that is smaller than the receiving opening of the upper portion by an extent that a substance that is received in one or both of the first and second volumes remains therein until acted upon by an amount of applied force. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of using a multi-well reservoir plate, the method comprising:
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adding at least one substance to at least one well of the reservoir plate; supporting the at least one substance in an upper volume portion of the at least one well for a desired amount of time, wherein a first portion of the at least one substance is supported by a tapered wall of the at least one well and another portion of the at least one substance spans an opening of a passage formed in and extending through a lower portion of the well, the at least one passage in fluid communication with the upper volume portion of the at least one well; and discharging at least some of the at least one substance from the upper volume portion of the well through and out of the passage in the lower portion of the well by applying an amount of force to the at least one substance. - View Dependent Claims (19, 20, 21, 22, 23)
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Specification