Novel Peptides that Bind to the Erythropoietin Receptor
First Claim
Patent Images
1. :
- A peptide, comprising an amino acid sequence selected from SEQ ID NOS;
1-668 according to FIGS. 1A-1PP.
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Abstract
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
92 Citations
58 Claims
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1. :
- A peptide, comprising an amino acid sequence selected from SEQ ID NOS;
1-668 according to FIGS. 1A-1PP. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- A peptide, comprising an amino acid sequence selected from SEQ ID NOS;
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15. :
- A peptide dimer, comprising;
(a) a first peptide chain; (b) a second peptide chain; and (c) a linking moiety connecting said first and second peptide chains, wherein at least one of said first peptide chain and said second peptide chain comprises an amino acid sequence selected from SEQ ID NOS;
1-668 according to FIGS. 1A-1PP; andwherein said peptide binds to and activates the erythropoietin receptor (EPO-R). - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
- A peptide dimer, comprising;
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34. :
- A method for treating a patient, comprising administering to a patient having a disorder characterized by a deficiency of erythropoietin or a low or defective red blood cell population a therapeutically effective amount of a peptide comprising an amino acid sequence selected from SEQ ID NOS;
1-668 according to FIGS. 1A-1PP. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
- A method for treating a patient, comprising administering to a patient having a disorder characterized by a deficiency of erythropoietin or a low or defective red blood cell population a therapeutically effective amount of a peptide comprising an amino acid sequence selected from SEQ ID NOS;
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47. :
- A pharmaceutical composition comprising;
(i) a peptide comprising an amino acid sequence selected from SEQ ID NOS;
1-668 according to FIGS. 1A-1PP; and(ii) a pharmaceutically acceptable carrier. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
- A pharmaceutical composition comprising;
Specification