PHARMACEUTICAL COMPOSITIONS INCLUDING LOW DOSAGES OF DESMOPRESSIN
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Accused Products
Abstract
The present invention is directed to a pharmaceutical composition comprising 0.5 ng to 20 μg desmopressin and a pharmaceutically acceptable carrier. The present invention is also directed to a pharmaceutical composition comprising desmopressin and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is effective to establish a steady plasma/serum desmopressin concentration in the range of from about 0.1 picograms desmopressin per mL plasma/serum to about 10.0 picogram desmopressin per mL plasma/serum. Articles of manufacture and methods of using the above invention are also disclosed.
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Citations
27 Claims
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1-18. -18. (canceled)
- 19. A method of producing an antidiuretic effect in a patient without inducing hyponatremia comprising administering to the patient a pharmaceutically effective amount of desmopressin ranging from about 0.5 ng/kg of body weight to about 285 ng/kg of body weight.
- 20. A method for inducing voiding postponement while reducing the risk of inducing hyponatremia comprising administering an amount of desmopressin therapeutically effective to produce an antidiuretic effect lasting for a maximum of between about 4 and about 6 hours.
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27. A method for inducing voiding postponement comprising administering to a patient a amount of desmopressin sufficient to produce in the patient a urine osmolality ranging above about 300 mOsm/kg for less than about 5 hours after administration.
Specification