Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
First Claim
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1. A method for opening the blood-brain barrier in the brain of a subject comprising:
- targeting a region of the brain of a subject for opening; and
applying an ultrasound beam by a single-element transducer through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject.
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Abstract
A system and method for opening the blood-brain barrier in the brain of a subject is disclosed. In some embodiments, a region of the brain of a subject is targeted for opening; and a focused ultrasound beam is applied through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject.
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Citations
25 Claims
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1. A method for opening the blood-brain barrier in the brain of a subject comprising:
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targeting a region of the brain of a subject for opening; and applying an ultrasound beam by a single-element transducer through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject. - View Dependent Claims (2, 3, 4, 5)
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6. A method for opening the blood-brain barrier in the brain of a subject comprising:
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targeting vasculature adjacent selected brain tissue of a subject for opening; and applying an ultrasound beam through the skull of the subject to the targeted vasculature to open the blood-brain barrier in the brain of the subject. - View Dependent Claims (7, 8, 9, 10)
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11. A system for opening the blood-brain barrier in the brain of a subject comprising:
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a targeting assembly for targeting a region of the brain of a subject for opening the blood-brain barrier thereof; and a transducer for applying an ultrasound beam through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject. - View Dependent Claims (12, 13, 14, 15)
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16. A system for opening the blood-brain barrier in the brain of a subject comprising:
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means for targeting a region of the brain of a subject for opening; and means for applying an ultrasound beam through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject. - View Dependent Claims (17, 18, 19, 20)
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21. A system for delivering a molecule through the blood-brain barrier in the brain of a subject comprising:
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a targeting assembly for targeting a region of the brain of a subject; a transducer for applying an ultrasound beam through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject; and an introducer for delivering a molecule through the blood-brain barrier of the subject. - View Dependent Claims (22, 23, 24, 25)
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Specification